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Table 1 Laboratory results before and during treatment with hydrocortisone, fludrocortisone and salt. (B- Baseline, S- Stimulated with 250 mcg of cortrosyn on DOL 3)

From: Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy

  Reference range DOL 2 DOL 3 DOL 10 7 weeks 3.75 months 5 months 8 months
Hydrocortisone (mg/m2/day)     15 30 20 12 11
Fludrocortisone (mg)      0.2 0.15 0.1 0.05
NaCl (gram)      1 2 1 1
ACTH (pg/ml) 7.2–63   135    15   
Cortisol (mcg/dl) 3–23   6.5 (B)      
10 (S)
Sodium (mmol/L) 134–144 142 144 134 137   138  
Potassium (mmol/L) 3.8–5.3 6.3 5.8 6.9 5.4    
Bicarbonate (mmol/L) 15–25 18 19 23 17.7   18.6  
Plasma Renin Activity (PRA) (ng/ml/hr) Premature:    174.1 0.933 1.6 0.618 1.2
1–7 Days:
11–167
1–11 Months:
2.35–37
Aldosterone (ng/dl) Premature:    100     
12–736
1–11 months:
5–90
17-Hydroxy progesterone (ng/dl) Premature 516 4853 (S)    45   < 10
186–472 (B)
334–1725 (S)
2 m-1 year: < 91
17-Hydroxy pregnenelone (ng/dl) Premature   > 4000(S)   21    
559–2906 (B)
831–9760 (S)
6 -11 m:
42–540
Dehydroepi-androsterone Sulfate (mcg/dl) 122–710 (B)   2415 (B)      
11-Deoxycortisol (ng/ml) < Or = 235 (B)   1431(B)      
Deoxycorticosterone (ng/dl) 28–78 (B)   65 (B)      
Corticosterone (ng/dl) 201–5030 (B)   992 (B)      
Androstenedione (ng/dl) 1-11 m:       < 10 15
< 10–37
Testosterone (ng/dl) 31–35 weeks 383       
Day 4
37–198
Dihydrotestosterone (ng/dl) Premature:   23      
10–53