Table 1 Laboratory results before and during treatment with hydrocortisone, fludrocortisone and salt. (B- Baseline, S- Stimulated with 250 mcg of cortrosyn on DOL 3)
From: Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy
Reference range | DOL 2 | DOL 3 | DOL 10 | 7 weeks | 3.75 months | 5 months | 8 months | |
|---|---|---|---|---|---|---|---|---|
Hydrocortisone (mg/m2/day) | 15 | 30 | 20 | 12 | 11 | |||
Fludrocortisone (mg) | 0.2 | 0.15 | 0.1 | 0.05 | ||||
NaCl (gram) | 1 | 2 | 1 | 1 | ||||
ACTH (pg/ml) | 7.2–63 | 135 | 15 | |||||
Cortisol (mcg/dl) | 3–23 | 6.5 (B) | ||||||
10 (S) | ||||||||
Sodium (mmol/L) | 134–144 | 142 | 144 | 134 | 137 | 138 | ||
Potassium (mmol/L) | 3.8–5.3 | 6.3 | 5.8 | 6.9 | 5.4 | |||
Bicarbonate (mmol/L) | 15–25 | 18 | 19 | 23 | 17.7 | 18.6 | ||
Plasma Renin Activity (PRA) (ng/ml/hr) | Premature: | 174.1 | 0.933 | 1.6 | 0.618 | 1.2 | ||
1–7 Days: | ||||||||
11–167 | ||||||||
1–11 Months: | ||||||||
2.35–37 | ||||||||
Aldosterone (ng/dl) | Premature: | 100 | ||||||
12–736 | ||||||||
1–11 months: | ||||||||
5–90 | ||||||||
17-Hydroxy progesterone (ng/dl) | Premature | 516 | 4853 (S) | 45 | < 10 | |||
186–472 (B) | ||||||||
334–1725 (S) | ||||||||
2 m-1 year: < 91 | ||||||||
17-Hydroxy pregnenelone (ng/dl) | Premature | > 4000(S) | 21 | |||||
559–2906 (B) | ||||||||
831–9760 (S) | ||||||||
6 -11 m: | ||||||||
42–540 | ||||||||
Dehydroepi-androsterone Sulfate (mcg/dl) | 122–710 (B) | 2415 (B) | ||||||
11-Deoxycortisol (ng/ml) | < Or = 235 (B) | 1431(B) | ||||||
Deoxycorticosterone (ng/dl) | 28–78 (B) | 65 (B) | ||||||
Corticosterone (ng/dl) | 201–5030 (B) | 992 (B) | ||||||
Androstenedione (ng/dl) | 1-11 m: | < 10 | 15 | |||||
< 10–37 | ||||||||
Testosterone (ng/dl) | 31–35 weeks | 383 | ||||||
Day 4 | ||||||||
37–198 | ||||||||
Dihydrotestosterone (ng/dl) | Premature: | 23 | ||||||
10–53 |