TY - JOUR AU - Gujral, Jasmine AU - Costin, Gertrude AU - Khurana, Divya AU - Yau, Mabel AU - Wallach, Elizabeth AU - Romero, Christopher J. AU - Wilkes, Meredith AU - Sethuram, Swathi AU - Rapaport, Robert PY - 2020 DA - 2020/09/09 TI - Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy JO - International Journal of Pediatric Endocrinology SP - 16 VL - 2020 IS - 1 AB - Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in infants exposed to nystatin in utero. SN - 1687-9856 UR - https://doi.org/10.1186/s13633-020-00087-1 DO - 10.1186/s13633-020-00087-1 ID - Gujral2020 ER -