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Table 1 characteristics of 9 pediatric cases of a DTC reported during the last 20 years

From: A synchronous papillary and follicular thyroid carcinoma presenting as a large toxic nodule in a female adolescent

  Sex Age Complaints TSH
miU/L (ref)
fT3
pmol/L (ref)
fT4
pmol/l (ref)
Antibodies US dimensions US structure Scintigraphy
Activity in surrounding tissue
FNAC Histology
Mircescu 2000 [8] F 11 y Painless cervical mass right sided
Tremor
↓ 0.03 5.7
(1.0–2.8)
> 75
(8–18)
Undetectable 45x37x28mm Numerous cystic lesions Suppresed activity Not mentioned PTC
Tfayli 2010 [9] F 11 y Heavy menses
Fatigue
Right thyroid mass
Undetectable 5.9
(1.9–3.2)
14.7
(9.4–23.7)
Undetectable 30–35 mm Large nonhomogenous nodule in right lobe Remaining weak activity Not diagnostic PTC
Damle 2011 [10] M 2 m Right sided neck swelling since birth
Clinical features of thyrotoxicosis
Thyrotoxicosis Thyrotoxicosis Thyrotoxicosis Not mentioned 34x22x20 mm Nodule Suppressed activity Moderately cellular smear with clusters and sheets of epithelial cells PTC
F 7 y Palpitations and tremor
Right nodule
0.01
(0.5–4.5)
7.4
(1.0–3.0)
27.9
(5.8–15.4)
50 × 50 mm Suppressed activity Epithelial cell clusters with nuclear overlapping, Follicular variant of PTC
Gabalec 2013 [11] F 15 y Thyroid nodule self-palpation
Sweating
Insomnia
0.01
(0.3–5.6)
  30.6
(7–15.9)
Undetectable 35x23x45mm Asymmetrical, enlarged left lobe completely filled with heterogeneous well demarcated nodule Suppressed activity Suspicious Follicular variant of PTC
Ruggeri 2013 [12] F 15 y Painless mass
Fatigue
Weight loss
Palpitations
0.001
(0.27–4.2)
7.7
(3.0–6.8)
25.9
(11.6–21.9)
Undetectable 35x30x21mm Increase in size, intense intranodular bloodflow, isoechoic, nonhomogenous, regular margins, peripheral halo Suppressed activity Follicular variant of PTC
Rees 2015 [13] F 16 y Left thyroid mass. Weight loss, tremor,
frequent bowel movement, hair loss. Feeling tearful and anxious
0.03
(0.53–3.59)
14.3
(3.5–7.7)
39.4
(12–20.6)
Undetectable 40 × 25 mm Hyperechoic, hypervascular nodule Suppressed activity   Follicular variant of PTC
Blackburn, 2018 [14] F 12 y Right-sided neck swelling, increasing in size over the previous four weeks ↓ < 0.03
3
9.1
(3.6–6.4)
10.1
(9–19)
Undetectable 21 × 17 × 17 mm Heterogeneous highly vascular mass Not mentioned FTC
Dy, 2018 [15] F 14 y Left-sided palpable thyroid lesion, increasing sweats, tremors and tachycardia 0.02
(0.4–5.6)
18.0
(11.6–19.3)
Not mentioned 34 × 21 × 29 mm Hypoechoic, heterogeneous and hypervascular Suppressed activity Benign FTC
  1. Abbreviations: ref, reference values; M, male; F, female; m, month; y, year; US, ultrasound; PTC, Papillary Thyroid Carcinoma; FTC, Follicular Thyroid Carcinoma