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Fig. 1 | International Journal of Pediatric Endocrinology

Fig. 1

From: Coexistence of paternally-inherited ABCC8 mutation and mosaic paternal uniparental disomy 11p hyperinsulinism

Fig. 1

a. Picture of the proband with no somatic features suggestive of BWS. 1b. 18F-Dopa PET scan showed accentuated 18F-dopa uptake in the pancreatic body, with a lesser degree of diffused activity in pancreatic head and tail, suggestive of a focal lesion. 1c-e. Histology of resected pancreatic tissue. c. The pancreas shows preserved acinar architecture with prominent islets of Langerhans (arrowhead), consist of coalescing nests and trabeculae of endocrine cells. d. High power field showing some islets containing isolated, enlarged, hyperchromatic nuclei, which is over 2 times the size of the nuclei in the adjacent islet cells. e. Immunohistochemical stains confirmed the nests and trabeculae of endocrine cells are positive for neuroendocrine marker chromogranin and many of them express insulin by immunohistochemistry

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