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Table 1 Characteristics: background, at GH start, after first-year GH treatment

From: Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria

  SGA GHD (all) Severe GHD (peak GH < 5 μg/L) Less-severe GHD (peak GH 5–10 μg/L)
n Mean SD Median p25 p75 n Mean SD Median p25 p75 n Mean SD Median p25 p75 n Mean SD Median p25 p75
Background
 Birth weight, SDS 169 −2.561 0.96 −2.50 − 2.93 − 2.03 121 − 0.441 0.9 − 0.43 − 1.21 0.27 65 − 0.19 0.94 − 0.14 − 0.85 0.47 56 −0.74 0.78 −0.77 −1.35 − 0.13
 Birth length, SDS 163 −2.771 1.02 − 2.65 −3.41 − 2.19 112 −0.591 0.89 −0.58 −1.23 −0.03 61 −0.48 0.87 −0.55 −1.1 0.17 51 −0.71 0.91 − 0.83 −1.4 −0.28
 Sex, % male 64       66       64            
 Father height, SDS 164 −1.402 1.12 − 1.48 −2.1 −0.47 118 −0.852 1.27 −0.97 −1.66 − 0.15 64 − 0.72 1.32 −0.67 − 1.65 0.24 54 −0.99 1.2 −1.05 − 1.95 − 0.26
 Mother height, SDS 163 −1.371 1.11 −1.28 −2.12 −0.61 119 −0.771 1.13 −0.78 −1.53 0.07 64 −0.82 1.16 −0.78 −1.55 0.07 55 −0.72 1.11 −0.61 −1.45 0.07
 MPH, SDS 163 −1.391 0.85 −1.42 −1.95 −0.85 118 −0.821 0.92 −0.82 −1.56 −0.27 64 −0.96 1.29 −0.96 −1.99 0.02 54 −1.05 0.98 −0.83 −1.87 −0.4
 Maximum GH peak, μg/L        122 4.9 2.6 4.8 3.0 7.1 66 2.9 1.4 3.0 1.9 4.1 56 7.4 1.4 7.3 6.0 8.4
At start GH treatment
 Age, years 171 7.5 2.3 7.5 5.4 9.2 122 6.7 2.9 6.5 4.4 8.8 66 6.5 3.1 5.9 4.2 8.6 56 6.96 2.8 7.7 5.3 8.9
 Height, SDS 171 −3.21 0.65 −3.06 −3.51 −2.77 122 −3.17 0.83 −3.2 −3.69 −2.71 66 −3.33 0.89 −3.32 −3.8 −2.81 56 −2.98 0.7 −2.9 − 3.43 − 2.59
 Weight, SDS 168 −3.341 1.21 −3.29 −4.1 −2.47 120 −2.531 1.19 −2.44 −3.36 −1.69 65 −2.57 1.22 −2.49 −3.34 −1.77 55 −2.48 1.15 −2.4 −3.4 − 1.6
 BMI, SDS 167 −1.281 1.2 −2.21 −2.13 −0.41 113 −0.331 1.13 −0.52 −1.06 0.4 62 −1.17 1.04 −0.46 −0.85 0.63 51 −0.53 1.22 −0.74 −1.18 0.27
 Height SDS minus MPH SDS 163 −1.831 0.87 −1.75 −2.28 −1.21 118 −2.361 1.14 −2.26 −3.04 −1.51 64 −2.58 1.27 −2.41 −3.31 −1.7 54 −2.11 0.9 −2.12 −2.66 −1.42
 GH dose, μg/kg*day 167 38.1 7.2 36.51 33.5 41.2 120 26.2 3,0 25.81 24.4 27.4 65 25.8 3.1 2.3 23.8 27.3 55 26.6 2.9 26,0 24.7 27.4
After first-year GH treatment
 Height, SDS 171 −2.64 0.71 −2.482 −2.98 −2.15 122 −2.35 0.75 −2.322 −2.75 −1.91 66 −2.35 0.78 −2.31 − 2.92 −1.77 56 − 2.35 0.71 − 2.34 −2.69 − 2.05
 ∆ BMI, SDSa 167 0.181 0.47 0.15 −0.15 0.44 120 − 0.211 0.59 − 0.19 − 0.54 0.18 65 − 0.27 0.68 − 0.23 − 0.57 0.2 55 − 0.14 0.47 − 0.14 − 0.48 0.17
 Height SDS minus MPH SDS 163 −1.251 0.91 − 1.15 − 1.78 −0.59 118 − 1.521 0.89 − 1.53 −2.19 − 0.89 64 − 1.58 1.01 −1.61 −2.47 − 0.89 54 − 1.45 0.72 − 1.5 − 1.97 − 0.94
 GH dose during first year, μg/kg*day 167 38.1 6.7 36.41 34,0 41.6 119 26.9 3.2 26.51 25,0 28.2 64 26.6 2.9 26.4 24.9 28.2 55 27.3 3.5 26.5 25,0 28.4
  1. SGA small for gestational age, GHD growth hormone deficiency, GH growth hormone, MPH midparental height, BMI body mass index; a Increase in BMI during first-year GH treatment; 1p < 0,001; 2p < 0,05