Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria

Straetemans, Saartje; Thomas, Muriel; Craen, Margarita; Rooman, Raoul; De Schepper, Jean

doi:10.1186/s13633-018-0064-3

International Journal of Pediatric Endocrinology

Table 1 Characteristics: background, at GH start, after first-year GH treatment

From: Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria

	SGA						GHD (all)						Severe GHD (peak GH < 5 μg/L)						Less-severe GHD (peak GH 5–10 μg/L)
	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75
Background
Birth weight, SDS	169	−2.56¹	0.96	−2.50	− 2.93	− 2.03	121	− 0.44¹	0.9	− 0.43	− 1.21	0.27	65	− 0.19	0.94	− 0.14	− 0.85	0.47	56	−0.74	0.78	−0.77	−1.35	− 0.13
Birth length, SDS	163	−2.77¹	1.02	− 2.65	−3.41	− 2.19	112	−0.59¹	0.89	−0.58	−1.23	−0.03	61	−0.48	0.87	−0.55	−1.1	0.17	51	−0.71	0.91	− 0.83	−1.4	−0.28
Sex, % male	64						66						64
Father height, SDS	164	−1.40²	1.12	− 1.48	−2.1	−0.47	118	−0.85²	1.27	−0.97	−1.66	− 0.15	64	− 0.72	1.32	−0.67	− 1.65	0.24	54	−0.99	1.2	−1.05	− 1.95	− 0.26
Mother height, SDS	163	−1.37¹	1.11	−1.28	−2.12	−0.61	119	−0.77¹	1.13	−0.78	−1.53	0.07	64	−0.82	1.16	−0.78	−1.55	0.07	55	−0.72	1.11	−0.61	−1.45	0.07
MPH, SDS	163	−1.39¹	0.85	−1.42	−1.95	−0.85	118	−0.82¹	0.92	−0.82	−1.56	−0.27	64	−0.96	1.29	−0.96	−1.99	0.02	54	−1.05	0.98	−0.83	−1.87	−0.4
Maximum GH peak, μg/L							122	4.9	2.6	4.8	3.0	7.1	66	2.9	1.4	3.0	1.9	4.1	56	7.4	1.4	7.3	6.0	8.4
At start GH treatment
Age, years	171	7.5	2.3	7.5	5.4	9.2	122	6.7	2.9	6.5	4.4	8.8	66	6.5	3.1	5.9	4.2	8.6	56	6.96	2.8	7.7	5.3	8.9
Height, SDS	171	−3.21	0.65	−3.06	−3.51	−2.77	122	−3.17	0.83	−3.2	−3.69	−2.71	66	−3.33	0.89	−3.32	−3.8	−2.81	56	−2.98	0.7	−2.9	− 3.43	− 2.59
Weight, SDS	168	−3.34¹	1.21	−3.29	−4.1	−2.47	120	−2.53¹	1.19	−2.44	−3.36	−1.69	65	−2.57	1.22	−2.49	−3.34	−1.77	55	−2.48	1.15	−2.4	−3.4	− 1.6
BMI, SDS	167	−1.28¹	1.2	−2.21	−2.13	−0.41	113	−0.33¹	1.13	−0.52	−1.06	0.4	62	−1.17	1.04	−0.46	−0.85	0.63	51	−0.53	1.22	−0.74	−1.18	0.27
Height SDS minus MPH SDS	163	−1.83¹	0.87	−1.75	−2.28	−1.21	118	−2.36¹	1.14	−2.26	−3.04	−1.51	64	−2.58	1.27	−2.41	−3.31	−1.7	54	−2.11	0.9	−2.12	−2.66	−1.42
GH dose, μg/kg*day	167	38.1	7.2	36.5¹	33.5	41.2	120	26.2	3,0	25.8¹	24.4	27.4	65	25.8	3.1	2.3	23.8	27.3	55	26.6	2.9	26,0	24.7	27.4
After first-year GH treatment
Height, SDS	171	−2.64	0.71	−2.48²	−2.98	−2.15	122	−2.35	0.75	−2.32²	−2.75	−1.91	66	−2.35	0.78	−2.31	− 2.92	−1.77	56	− 2.35	0.71	− 2.34	−2.69	− 2.05
∆ BMI, SDS^a	167	0.18¹	0.47	0.15	−0.15	0.44	120	− 0.21¹	0.59	− 0.19	− 0.54	0.18	65	− 0.27	0.68	− 0.23	− 0.57	0.2	55	− 0.14	0.47	− 0.14	− 0.48	0.17
Height SDS minus MPH SDS	163	−1.25¹	0.91	− 1.15	− 1.78	−0.59	118	− 1.52¹	0.89	− 1.53	−2.19	− 0.89	64	− 1.58	1.01	−1.61	−2.47	− 0.89	54	− 1.45	0.72	− 1.5	− 1.97	− 0.94
GH dose during first year, μg/kg*day	167	38.1	6.7	36.4¹	34,0	41.6	119	26.9	3.2	26.5¹	25,0	28.2	64	26.6	2.9	26.4	24.9	28.2	55	27.3	3.5	26.5	25,0	28.4

SGA small for gestational age, GHD growth hormone deficiency, GH growth hormone, MPH midparental height, BMI body mass index; ^a Increase in BMI during first-year GH treatment; ¹p < 0,001; ²p < 0,05

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