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Table 2 Comparison of BMI, HbA1c, FPG, Basal and Bolus Insulin Doses at Baseline and 26 weeks after IDeg Treatment by Age

From: Real-world efficacy and safety of insulin degludec with mealtime rapid-acting insulin in type 1 diabetes in Indian pediatric population

Characteristics

Baseline

26 weeks

BMI (kg/m2) (SDS)

 Overall population (N = 30)

16.99 ± 3.364 (0.04 ± 0.97)

17.39 ± 3.005 (0.15 ± 0.89)

 1–6 years (n = 8)

15.28 ± 1.274 (0.04 ± 0.81)

15.83 ± 1.199 (0.48 ± 0.63)

 6–12 years (n = 14)

16.79 ± 3.297 (0.10 ± 0.91)

17.18 ± 2.653 (0.20 ± 0.91)

  > 12 years (n = 8)

19.04 ± 4.108 (− 0.16 ± 1.11)

19.33 ± 3.964 (− 0.15 ± 1.06)

HbA1c (%)

 Overall population (N = 30)

9.65 ± 1.998

8.60 ± 1.631*

 1–6 years (n = 8)

8.59 ± 0.753

8.31 ± 0.930

 6–12 years (n = 14)

10.32 ± 2.213

8.50 ± 1.024*#

  > 12 years (n = 8)

9.53 ± 2.159

9.06 ± 2.802

FPG (mg/dL)

 Overall population (N = 30)

156.93 ± 42.373

109.37 ± 28.531*

 1–6 years (n = 8)

136.50 ± 12.862

105.75 ± 26.114*

 6–12 years (n = 14)

176.43 ± 49.781

108.36 ± 28.678*

  > 12 years (n = 8)

143.25 ± 34.919

114.75 ± 33.363*

Insulin dose (U/kg of body weight/day)

 Basal insulin

  Overall population (N = 30)

0.42 ± 0.134

0.46 ± 0.139*

  1–6 years (n = 8)

0.38 ± 0.120

0.41 ± 0.109

  6–12 years (n = 14)

0.46 ± 0.165

0.52 ± 0.163

   > 12 years (n = 8)

0.40 ± 0.069

0.41 ± 0.074

 Bolus insulin

  Overall population (N = 30)

0.49 ± 0.208

0.35 ± 0.155*

  1–6 years (n = 8)

0.37 ± 0.115

0.27 ± 0.077*

  6–12 years (n = 14)

0.57 ± 0.255

0.39 ± 0.176*

   > 12 years (n = 8)

0.48 ± 0.128

0.37 ± 0.156*

  1. BMI body mass index, FPG fasting plasma glucose, HbA1c glycated hemoglobin, SDS Standard Deviation Score
  2. *P < 0.05 versus baseline (paired t-test)
  3. #P < 0.05 versus 1–6 years (t-test)