Body composition, adipokines, bone mineral density and bone remodeling markers in relation to IGF-1 levels in adults with Prader-Willi syndrome

Table 3 Correlation coefficients of measurements of body composition, IGF-1, appetite regulating peptides and measurements of glucose homeostasis within the PWS patients (total group)

	BMI	FM	LBM	IGF-1	Glucose	HbA1c	Insulin	HOMA	Leptin	Ghrelin	Resistin	Adiponectin	Hs-CRP
BMI (kg/m²)	1.00	0.96**	0.75**	− 0.18	0.19	0.16	0.44	0.55*	0.83**	−0.44	0.58*	−0.31	0.77**
FM (g, DXA)	0.96**	1.00	0.69**	−0.14	0.19	0.18	0.36	0.46	0.78**	−0.33	0.53*	−0.30	0.88**
LBM (g, DXA)	0.75**	0.69**	1.00	0.02	0.02	0.32	0.46	0.51	0.54*	−0.46	0.69**	−0.44	0.66**
IGF-1 (nmol/L)	−0.18	−0.14	0.02	1.00	−0.03	−0.18	0.26	0.04	−0.04	−0.11	0.01	−0.39	− 0.27
Glucose (mmol/L)	0.19	0.19	0.02	−0.03	1.00	0.14	0.67**	0.65*	0.51*	−0.34	0.20	−0.45	0.39
HbA1c (%)	0.16	0.18	0.32	−0.18	0.14	1.00	0.02	0.09	0.14	0.10	0.35	−0.58*	0.41
Insulin (pmol/L)	0.44	0.36	0.46	0.26	0.67**	0.02	1.00	0.99**	0.69**	−0.48	0.39	−0.46	0.33
HOMA (index)	0.55*	0.46	0.51	0.04	0.65*	0.09	0.99**	1.00	0.67**	−0.58*	0.54*	−0.34	0.41
Leptin (μg/L)	0.83**	0.78**	0.54*	−0.04	0.51*	0.14	0.69**	0.67**	1.00	−0.41	0.37	−0.39	0.66**
Ghrelin (ng/L)	−0.44	−0.33	− 0.46	−0.11	− 0.34	0.10	− 0.48	−0.58*	− 0.41	1.00	− 0.31	0.29	− 0.24
Resistin (ng/ml)	0.58*	0.53*	0.69**	0.01	0.20	0.35	0.39	0.54*	0.37	−0.31	1.00	−0.56*	0.51*
Adiponectin (mg/L)	−0.31	−0.30	− 0.44	−0.39	− 0.45	−0.58*	− 0.46	−0.34	− 0.39	0.29	− 0.56*	1.00	− 0.47
Hs-CRP (mg/L)	0.77**	0.88**	0.66**	−0.27	0.39	0.41	0.33	0.41	0.66**	−0.24	0.51*	−0.47	1.00

ISSN: 1687-9856