Table 2 IGF-1 levels, markers of metabolic status, bone remodeling markers and appetite regulating factors in PWS patients (panel A) and IGF-1 levels in healthy controls (panel B)

Panel A

Total group

Men

Women

(N = 15)

IQR

(N = 4)

IQR

(N = 11)

IQR

IGF-1, nmol/L

14.6

7.7

16.0

11.9

14.6

7.7

IGF-1, SDS

−1.94

1.24

−1.55

1.24

−1.96

1.00

IGFBP-3, mg/L

4.30

1.38

4.73

2.87

4.02

1.89

Calcium, mmol/L

2.42

0.17

2.43

0.30

2.42

0.09

Albumin, g/L

43.0

5.0

42.5

12.0

43.0

4.0

Creatinine, μmol/L

69.0

10.0

71.0

28.0

69.0

10.0

Alkaline phosphatase, U/L

103.0

54.0

98.0

57.0

106.0

61.0

Phosphate, mmol/L

1.12

0.31

0.91

0.47

1.16

0.26

25(OH)D, nmol/L

61.0

34.0

83.5

66.0

54.0

31.0

Osteocalcin, nmol/L

0.90

2.49

0.77

2.28

1.24

2.49

Total cholesterol, mmol/L

4.8

1.8

4.9

2.6

4.8

1.8

HDL, mmol/L

1.3

0.5

1.2

0.7

1.3

0.4

LDL, mmol/L

2.9

1.2

2.1

NA

3.2

1.0

Triglycerides, mmol/L

0.80

0.30

1.75

2.60

0.80

0.30

Glucose, mmol/L

4.2

1.0

4.2

0.2

4.0

1.3

HbA1c, %

5.4

0.4

5.6

3.1

5.4

0.4

Insulin, pmol/L

30.6

36.8

37.2

179.1

29.1

38.5

HOMA index

0.58

0.62

0.66

3.04

0.55

0.64

Leptin, μg/L

21.5

33.2

20.1

38.7

24.9

33.2

Ghrelin, ng/L

2476

2080

2118

2201

2612

2092

Resistin, ng/ml

4.4

3.6

4.3

5.7

4.4

3.6

Adiponectin, mg/L

13.9

6.7

13.2

9.1

13.9

6.4

Hs-CRP, mg/L

4.04

10.39

3.48

8.01

7.54

19.68

Urine Calcium, mmol/24 h

0.20

0.5

0.55

1.1

0.20

0.2

Urine Creatitine, mmol/24 h

1.74

1.47

3.27

2.86

1.70

0.69

Urine Hydroxyprolin, mmol/24 h

0.046

0.028

0.055

0.087

0.046

0.027

Urine Hydroxyprolin/Creatinin ratio

25.2

21.2

23.2

40.9

25.2

20.4

Panel B

Total group

Men

Women

(N = 14)

IQR

(N = 7)

IQR

(N = 7)

IQR

IGF-1, nmol/L

21.8

11.6

21.4

14.2

22.1

10.5

IGF-1, SDS

−0.79

1.06

−1.00

1.07

− 0.76

1.72