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Table 1 Body composition characteristics and measurements of bone mineral density in PWS patients and control group

From: Body composition, adipokines, bone mineral density and bone remodeling markers in relation to IGF-1 levels in adults with Prader-Willi syndrome

  PWS Controls
Total group   Men   Women   Total group   Men   Women  
(N = 15) IQR (N = 4) IQR (N = 11) IQR (N = 14) IQR (N = 7) IQR (N = 7) IQR
Age, years 22.0 12.9 26.6 18.3 20.9 12.9 28.5 18.0 28.4 17.4 28.7 20.1
Sex
 Female, % 73.3       50.0      
 Male, % 26.7       50.0      
Genetic subtype
 Deletion, % 93.3            
 UPD, % 6.7            
Height, m 1.58** 0.08 1.60 0.09 1.57 0.10 1.77 0.17 1.86## 0.066 1.69 0.048
Weight, kg 69.5 33.6 67.9 32.9 70.3 37.1 73.1 15.9 79.1# 15.9 65.2 14.1
BMI, kg/m2 27.5* 16.7 26.1 13.2 32.1 20.3 22.4 4.6 22.7 5.1 22.0 5.8
Waist, cm 94.8* 27.5 94.3 17.1 94.8 43.8 80.2 19.3 84.5 11.4 71.2 24.2
Hip, cm 107 33.3 102.5 21.1 120.2 34.2 98.9 8.0 102.1 5.4 97.8 15.3
WHR 0.87* 0.13 0.93 0.12 0.87 0.10 0.82 0.14 0.84# 0.07 0.73 0.10
FM, kg (BIA) 28.5** 23.5 25.4 21.6 30.1 23.5 14.2 9.9 13.8 2.9 14.5 10.0
FFM, kg (BIA) 44.2** 16.2 44.2 16.1 44.2 16.2 56.2 18.0 66.2# 13.6 48.5 5.7
FM, % (BIA) 42.4** 12.4 37.5 12.3 42.4 11.1 20.6 12.3 16.7 4.8 25.1 12.1
FFM, % (BIA) 57.6** 12.4 62.5 12.4 57.6 11.1 79.4 12.3 83.3 4.8 74.9 12.1
BMC, % (BIA) 30.0** 11.4 32.5 8.1 29.7 12.2 42.8 9.7 44.5 7.3 40.3 22.1
BMC Lumbar spine, g (DXA) 41.0 13.8 41.7 17.0 41.0 11.4  
BMD Lumbar spine, g/cm2 (DXA) 0.91 0.17 0.80 0.28 0.93 0.20
T-score Lumbar spine, SDS (DXA) −1.4 2.0 −2.6# 2.5 −0.9 1.5
Z-score Lumbar spine, SDS (DXA) −1.7 1.4 −2.6 2.4 − 1.0 1.7
BMC Total hip, g (DXA) 23.0 5.1 22.9 3.5 23.0 8.4
BMD Total hip, g/cm2 (DXA) 0.76 0.10 0.74 0.13 0.76 0.15
T-score Total hip, SDS (DXA) −1.6 0.9 −2.0# 0.9 −1.2 1.5
Z-score Total hip, SDS (DXA) −1.5 1.1 −2.0 0.8 −1.4 1.3
Total BMC, g (DXA) 1763 386 1684 368 1763 423
Total BMD, g/cm2 (DXA) 0.99 0.13 0.95 0.14 0.99 0.14
FM, kg (DXA) 33.5 19.4 28.5 17.1 39.5 26.5
LBM, kg (DXA) 40.5 13.0 41.3 13.1 40.5 15.3
FM, % (DXA) 45.1 11.4 40.4 9.3 47.8 12.5
  1. BMI body mass index, WHR waist-to-hip ratio, FM fat mass, FFM fat free mass, BMC bone mineral content, BMD bone mineral density, LBM lean body mass
  2. All data are presented as median with interquartile range (IQR)
  3. * Significant difference when compared to control group, p < 0.05; ** p < 0.01
  4. # Significant difference when compared to other sex within group, p < 0.05; ## p < 0.01
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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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