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Table 3 Average association analysis using a dominant model of genetic variants and their effect on hormone levels during glucocorticoid treatments

From: Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and pharmacokinetic profiles: a pilot study in children with congenital adrenal hyperplasia

Hormone

Drug

Gene

CHR

SNP

Basepair

Minor allele

N

P value

Androstenedione

Prednisone

NR3C1

5

rs41423247

142778575

C

8

0.004

17-OHP

Dexamethasone

ABCB1

7

rs1045642

87138645

A

9

0.025

17-OHP

Dexamethasone

ABCB1

7

rs2032582

87160618

A

9

0.025

17-OHP

Dexamethasone

ABCB1

7

rs1128503

87179601

A

9

0.025

  1. Abbreviations: CHR chromosome, SNP single nucleotide polymorphism, N number, 17-OHP 17-hydroxyprogesterone, NR3C1 nuclear receptor subfamily 3 group C member 1, ABCB1 ATP-binding cassette sub-family B
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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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