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Table 1 The categories of patients with CO-GHD according to aetiology and centres distribution is shown as (A, B, C, D)

From: An audit of the management of childhood-onset growth hormone deficiency during young adulthood in Scotland

  Total number of cases 130 IGHD MPHD*
48/130 (37 %) 82/130 (63 %)
Congenital n (%) (A,B,C,D) 38/130 (29 %) 12 (8,1,2,1) 26 (14,3,4,5)
 -Pituitary axial structural abnormalities (A,B,C,D) 24 9 (6,1,1,1) 15 (6,3,1,5)
 -Midline axial structure defects (SOD) (A,B,C,D) 14 3 (2,0,1,0) 11 (8,0,3,0)
Oncology/cranial irradiation n (%) (A,B,C,D) 51/130 (40 %) 8 (5,3,0,0) 43 (18,19,4,2)
 - Craniopharyngioma (A,B,C,D) 15 15 (6,7,1,1)
 - Hematologic malignancies (A,B,C,D) 12 4 (4,0,0,0) 8 (6,0,1,1)
 - Medulloblastoma (A,B,C,D) 6 1 (0,1,0,0) 5 (1,4,0,0)
 - Other CNS tumors (A,B,C,D) 18 3 (1,2,0,0) 15 (5,8,2,0)
Idiopathica n (%) (A,B,C,D) 15/130 (11 %) 13 (7,1,5,0) 2 (1,1,0,0)
Othersb n (%) (A,B,C,D) 26/130 (20 %) 15 (12,1,1,1) 11 (5,3,2,1)
 -Crohn's disease (A,B,C,D) 4 4 (3,0,0,1)
 -Coeliac disease (A,B,C,D) 2 2 (0,1,1,0)
 -Haematological diseasesc (A,B,C,D) 2 1 (1,0,0,0) 1 (1,0,0,0)
 -Other diseasesd (A,B,C,D) 11 8 (6,1,1,0) 3 (0,2,1,0)
 -Syndromese(A,B,C,D) 6 2 (2,0,0,0) 4 (3,0,0,1)
 -Acquired brain injury (A,B,C,D) 1 1 (1,0,0,0)
  1. Data are presented as the numbers of patients and percentages are given in parentheses
  2. *33/82 patients with one additional pituitary hormone deficiency, 17/82 with two additional deficiencies, 19/82 with three and 13/82 with four additional deficiencies ‘panhypopituitarism’
  3. IGHD, isolated growth hormone deficiency; MPHD, multiple-pituitary hormone deficiencies; SOD, Septo-optic dysplasia
  4. aNormal pituitary MRI, GHD is not associated with other conditions
  5. bNormal pituitary MRI (or no MRI report), but GHD is associated with other conditions
  6. c(Thalassemia, X-linked Sideroblastic Anaemia)
  7. d(Microephaly with learning disability, history of intrauterine growth retardation, gastrochisis with history of small for gestational age, Asthma, joint hypermobility syndrome, pesudohypoparathyrodism)
  8. e(Charge syndrome, Noonan syndrome, Kallman Syndrome, trisomy 22, Klinefelter's syndrome, Turner's syndrome with GHD)