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Table 2 Clinical and biochemical data of girls with precocious puberty (PP) and premature thelarche (PT)

From: Increasing incidence of premature thelarche in the Central Region of Denmark - Challenges in differentiating girls less than 7 years of age with premature thelarche from girls with precocious puberty in real-life practice

Variable

PP

n=

PT

n=

P-value

Age at referral (years)a

5.9 (1.0-6.9)

27

1.3 (0.5-6.9)

164

0.000

European origin (%)

70.4

27

89.6

164

0.012

BMI SDS

+0.8 (0.3-1.3)

27

-0.3 (-0.5-(-) 0.1)

132

0.000

Bone age advancement (months)b

23.0 (3.0-48.0)

23

4.0 (1.0-19.0)

64

0.000

Estradiol (pg/mL)a

30.0 (18.0-137.0)

13

18.4 (13.0-85.0)

77

0.288

Inhibin B (pg/mL)

44.2 (23.9-64.4)

12

30.2 (25.6-34.7)

50

0.165

TSH (IU/L)

2.6 (2.1-3.1)

17

2.5 (2.2-2.8)

73

0.827

SHBG (nmol/L)

81.1 (60.2-101.9)

12

114.5 (102.3-126.8)

37

0.007

LH0 (IU/L)b

0.4 (0.1-3.0)

19

0.3 (0.05-1.0)

46

0.016

LH30 (IU/L)b

7.2 (3.0-45.0)

19

3.8 (0.6-24.0)

47

0.000

FSH0 (IU/L)b

2.9 (0.9-8.4)

19

2.85 (0.6-17.3)

46

0.891

FSH30 (IU/L)b

9.3 (2.3-27.7)

19

18.9 (0.8-77.9)

47

0.001

Basal LH/FSH ratiob

0.2 (0.02-0.71)

19

0.1 (0.02-1.25)

46

0.031

Peak LH/FSH ratiob

0.7 (0.26-2.67)

19

0.2 (0.05-1.25)

47

0.000

  1. Results are presented as mean values with 95 % confidence intervals
  2. aIndicates non-parametric tests where results are presented as median values and ranges. bIndicates parametric test with ln-tranformed data where results are presented as the untransformed median values and ranges