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Table 2 Timing of development of pituitary hormone deficiencies in patients with cns malformations

From: Etiological and clinical characteristics of central diabetes insipidus in children: a single center experience

Etiology Age at diagnosis of CNS abnormality Time from diagnosis of CNS abnormality to diagnosis of hormone deficiencies
Ectopic Pituitary 2 months ACTH, GH, TSH, at presentation
ADH, 1 year
Holoprosencephaly 3 months ADH, at presentation
TSH, 2 years
Pituitary Hypoplasia 13 years GH, at presentation
TSH, 9 months
ADH, 2 years
FSH, LH, 3 years
Septo-Optic Dysplasia 2 days ACTH, GH, TSH, at presentation
ADH, 2 months
Septo-Optic Dysplasia 4 months GH,12 years
ACTH, ADH, TSH, 13 years
Septo-Optic Dysplasia 8 months ADH, GH, at presentation
TSH, 1 year
Septo-Optic Dysplasia 22 months ADH, GH, at presentation
ACTH, 2 years