Table 2 Timing of development of pituitary hormone deficiencies in patients with cns malformations
Etiology | Age at diagnosis of CNS abnormality | Time from diagnosis of CNS abnormality to diagnosis of hormone deficiencies |
|---|---|---|
Ectopic Pituitary | 2 months | ACTH, GH, TSH, at presentation ADH, 1 year |
Holoprosencephaly | 3 months | ADH, at presentation TSH, 2 years |
Pituitary Hypoplasia | 13 years | GH, at presentation TSH, 9 months ADH, 2 years FSH, LH, 3 years |
Septo-Optic Dysplasia | 2 days | ACTH, GH, TSH, at presentation ADH, 2 months |
Septo-Optic Dysplasia | 4 months | GH,12 years ACTH, ADH, TSH, 13 years |
Septo-Optic Dysplasia | 8 months | ADH, GH, at presentation TSH, 1 year |
Septo-Optic Dysplasia | 22 months | ADH, GH, at presentation ACTH, 2 years |