Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

Table 3 Multivariable models for peak cortisol

	Age (years)		Weight (kg)		Height (m)		BSA (m²)		Height z-score
	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value
Age or size factor	−6.6	0.01*	−5.9	0.01*	−135.3	0.001 **	−221.3	0.01*	−70.8	0.02*
Sex (vs female)	−46.4	0.05*	−45.7	0.05	−45.1	0.05	−45.2	0.06
Indication for testing (vs GH sufficient short stature)
GHD		NS		NS		NS		NS		NS
Concern for multi-pituitary abnormalities	−67	0.05*	−137	0.06	−63	0.06	−173	0.07		NS
Neoplasm with risk to pituitary		NS		NS		NS		NS		NS
Exogenous glucocorticoid exposure	−249	<0.0005**	−398	<0.0005**	−242	<0.0005**	−425	<0.0005**		NS
Known multi-pituitary abnormalities	−104	0.02*	−244.0	0.03*	−94	0.04*		NS		NS
Interaction variables (vs GH sufficient group*age or size factor)
GHD*(age or size factor)				NS				NS		NS
Concern for multi-pituitary*(age or size factor)				NS				NS		NS
Neoplasm*(age or size factor)				NS				NS		NS
Exogenous glucocorticoids*(age or size factor)			6.4	0.02*			212	0.05*	129.3	<0.0005**
Known multi-pituitary*(age or size factor)				NS				NS		NS
Baseline cortisol (nmol/L)	0.59	<0.0005**	0.60	<0.0005**	0.58	<0.0005**	0.60	<0.0005**	0.65	<0.0005**
Peak ACTH (pmol/L)	2.56	<0.0005**	2.49	<0.0005**	2.47	<0.0005**	2.49	<0.0005**	2.20	<0.0005**
R², n	0.5092, 222		0.5201, 222		0.5182, 222		0.5196, 222		0.5481, 222

ISSN: 1687-9856