Skip to main content

Advertisement

Table 3 Multivariable models for peak cortisol

From: Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

  Age (years) Weight (kg) Height (m) BSA (m2) Height z-score
  Coefficient p-value Coefficient p-value Coefficient p-value Coefficient p-value Coefficient p-value
Age or size factor −6.6 0.01* −5.9 0.01* −135.3 0.001 ** −221.3 0.01* −70.8 0.02*
Sex (vs female) −46.4 0.05* −45.7 0.05 −45.1 0.05 −45.2 0.06   
Indication for testing (vs GH sufficient short stature)
GHD   NS   NS   NS   NS   NS
Concern for multi-pituitary abnormalities −67 0.05* −137 0.06 −63 0.06 −173 0.07   NS
Neoplasm with risk to pituitary   NS   NS   NS   NS   NS
Exogenous glucocorticoid exposure −249 <0.0005** −398 <0.0005** −242 <0.0005** −425 <0.0005**   NS
Known multi-pituitary abnormalities −104 0.02* −244.0 0.03* −94 0.04*   NS   NS
Interaction variables (vs GH sufficient group*age or size factor)
GHD*(age or size factor)     NS     NS   NS
Concern for multi-pituitary*(age or size factor)     NS     NS   NS
Neoplasm*(age or size factor)     NS     NS   NS
Exogenous glucocorticoids*(age or size factor)    6.4 0.02*    212 0.05* 129.3 <0.0005**
Known multi-pituitary*(age or size factor)     NS     NS   NS
Baseline cortisol (nmol/L) 0.59 <0.0005** 0.60 <0.0005** 0.58 <0.0005** 0.60 <0.0005** 0.65 <0.0005**
Peak ACTH (pmol/L) 2.56 <0.0005** 2.49 <0.0005** 2.47 <0.0005** 2.49 <0.0005** 2.20 <0.0005**
R2, n 0.5092, 222 0.5201, 222 0.5182, 222 0.5196, 222 0.5481, 222
  1. *p-value <0.05, **p-value < 0.005 by multivariate linear regression