| Peak cortisol (nmol/L) | Delta cortisol (nmol/L) | ||
---|---|---|---|---|
 | Coefficient | p-value | Coefficient | p-value |
Age (years) | −7.6 | 0.02* |  | NS |
Weight (kg) | −2.5 | 0.002 ** | −1.4 | 0.06# |
Weight inverse (1/kg) | 1153.9 | 0.004 ** | Â | NS |
Height (m) | −174.1 | 0.001 ** | −85.9 | 0.08# |
BMI (kg/m2) | −6.5 | 0.04* |  | NS |
BSA (m2) | −123.8 | 0.001 ** | −67.4 | 0.05# |
BMI z-score | −14.6 | NS |  | NS |
Height z-score | −41.7 | <0.0005** | −33.4 | <0.005** |
Sex (vs female) | −42.8 | 0.18# | −19.1 | NS |
Race | Â | NS | Â | NS |
Ethnicity (Hispanic/Latino vs Non-Hispanic/Latino) |  | NS | −94.3 | 0.09# |
Pubertal status (vs Tanner I) | Â | 0.21 | Â | 0.09# |
Tanner II-IV | Â | NS | Â | NS |
Tanner V | −115.2 | 0.14# | −154.7 | 0.03* |
Pubic hair development (yes vs no) | Â | NS | Â | NS |
Indication for testing (vs GH sufficient short stature) | Â | <0.0005** | Â | <0.0005** |
GHD | Â | NS | Â | NS |
Concern for multi-pituitary abnormalities | −65 | 0.11# | −55.1 | 0.16 |
Neoplasm with risk to pituitary | Â | NS | Â | NS |
Exogenous glucocorticoid exposure | −312.7 | <0.0005** | −239.0 | <0.0005** |
Known multi-pituitary abnormalities | −133.7 | 0.02* | −105.3 | 0.05 |
Time of testing (PM vs AM) | −40.1 | 0.17# | −62.2 | 0.02* |
Baseline cortisol (nmol/L) | 0.72 | <0.0005** | −0.35 | <0.0005** |
Baseline ACTH (pmol/L) | 10.6 | 0.01* | −5.9 | 0.11# |
Delta ACTH (pmol/L) | 3.4 | <0.0005** | 4.0 | <0.0005** |
Peak ACTH (pmol/L) | 3.6 | <0.0005** | 3.6 | <0.0005** |