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Table 2 Bivariable analysis of peak and delta cortisol

From: Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

  Peak cortisol (nmol/L) Delta cortisol (nmol/L)
  Coefficient p-value Coefficient p-value
Age (years) −7.6 0.02*   NS
Weight (kg) −2.5 0.002 ** −1.4 0.06#
Weight inverse (1/kg) 1153.9 0.004 **   NS
Height (m) −174.1 0.001 ** −85.9 0.08#
BMI (kg/m2) −6.5 0.04*   NS
BSA (m2) −123.8 0.001 ** −67.4 0.05#
BMI z-score −14.6 NS   NS
Height z-score −41.7 <0.0005** −33.4 <0.005**
Sex (vs female) −42.8 0.18# −19.1 NS
Race   NS   NS
Ethnicity (Hispanic/Latino vs Non-Hispanic/Latino)   NS −94.3 0.09#
Pubertal status (vs Tanner I)   0.21   0.09#
Tanner II-IV   NS   NS
Tanner V −115.2 0.14# −154.7 0.03*
Pubic hair development (yes vs no)   NS   NS
Indication for testing (vs GH sufficient short stature)   <0.0005**   <0.0005**
GHD   NS   NS
Concern for multi-pituitary abnormalities −65 0.11# −55.1 0.16
Neoplasm with risk to pituitary   NS   NS
Exogenous glucocorticoid exposure −312.7 <0.0005** −239.0 <0.0005**
Known multi-pituitary abnormalities −133.7 0.02* −105.3 0.05
Time of testing (PM vs AM) −40.1 0.17# −62.2 0.02*
Baseline cortisol (nmol/L) 0.72 <0.0005** −0.35 <0.0005**
Baseline ACTH (pmol/L) 10.6 0.01* −5.9 0.11#
Delta ACTH (pmol/L) 3.4 <0.0005** 4.0 <0.0005**
Peak ACTH (pmol/L) 3.6 <0.0005** 3.6 <0.0005**
  1. #p-value <0.2 (for use in multivariate analysis); *p-value;<0.05, **p-value < 0.005