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Table 2 Bivariable analysis of peak and delta cortisol

From: Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

 

Peak cortisol (nmol/L)

Delta cortisol (nmol/L)

 

Coefficient

p-value

Coefficient

p-value

Age (years)

−7.6

0.02*

 

NS

Weight (kg)

−2.5

0.002 **

−1.4

0.06#

Weight inverse (1/kg)

1153.9

0.004 **

 

NS

Height (m)

−174.1

0.001 **

−85.9

0.08#

BMI (kg/m2)

−6.5

0.04*

 

NS

BSA (m2)

−123.8

0.001 **

−67.4

0.05#

BMI z-score

−14.6

NS

 

NS

Height z-score

−41.7

<0.0005**

−33.4

<0.005**

Sex (vs female)

−42.8

0.18#

−19.1

NS

Race

 

NS

 

NS

Ethnicity (Hispanic/Latino vs Non-Hispanic/Latino)

 

NS

−94.3

0.09#

Pubertal status (vs Tanner I)

 

0.21

 

0.09#

Tanner II-IV

 

NS

 

NS

Tanner V

−115.2

0.14#

−154.7

0.03*

Pubic hair development (yes vs no)

 

NS

 

NS

Indication for testing (vs GH sufficient short stature)

 

<0.0005**

 

<0.0005**

GHD

 

NS

 

NS

Concern for multi-pituitary abnormalities

−65

0.11#

−55.1

0.16

Neoplasm with risk to pituitary

 

NS

 

NS

Exogenous glucocorticoid exposure

−312.7

<0.0005**

−239.0

<0.0005**

Known multi-pituitary abnormalities

−133.7

0.02*

−105.3

0.05

Time of testing (PM vs AM)

−40.1

0.17#

−62.2

0.02*

Baseline cortisol (nmol/L)

0.72

<0.0005**

−0.35

<0.0005**

Baseline ACTH (pmol/L)

10.6

0.01*

−5.9

0.11#

Delta ACTH (pmol/L)

3.4

<0.0005**

4.0

<0.0005**

Peak ACTH (pmol/L)

3.6

<0.0005**

3.6

<0.0005**

  1. #p-value <0.2 (for use in multivariate analysis); *p-value;<0.05, **p-value < 0.005