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Table 1 Subject characteristics by indication for testing

From: Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

Indication for testing Presumed GH sufficient short stature (GH ≥ 10 μg/L) Possible GHD (GH < 10 μg/L) Concern for multiple pituitary abnormalities Neoplasm with risk to pituitary Exogenous glucocorticoid exposure Known multiple pituitary abnormalities p-valuea
n 35 33 52 50 35 17 -
Sex (% female) 34 % 27 % 29 % 16 % 34 % 29 % 0.4
Age (years) 9.1 (4.6) 8.4 (4.1) 7.3 (5.0) 10.1 (3.0) 8.1 (4.9) 12.6 4.2) 0.0002
Tanner stage (Breast/Genital)
 I 28 (80 %) 29 (88 %) 44 (85 %) 33 (66 %) 25 (71 %) 7 (41 %) <0.0005
 II–IV 7 (20 %) 4 (12 %) 7 (13 %) 17 (34 %) 6 (17 %) 7 (41 %)  
 V 0 0 1 (2 %) 0 4 (11 %) 3 (18 %)  
Presence of pubic hair
 No 29 (83 %) 32 (97 %) 47 (90 %) 32 (64 %) 27 (77 %) 8 (47 %) <0.0005
 Yes 6 (17 %) 1 (3 %) 5 (10 %) 18 (36 %) 8 (23 %) 9 (53 %)  
Weight (kg) 23.6 (11.1) 24.5 (14.2) 25.9 (17.4) 31.8 (13.1) 31.0 (22.9) 47.5 (22.4) <0.0005
BMI z-score −0.50 (0.98) −0.04 (1.25) 0.55 (1.12) 0.27 (1.05) 0.45 (1.36) 0.57 (1.53) 0.0009
Height z-score −2.8 (0.8) −2.6 (0.9) −1.8 (1.6) −1.6 (1.4) −1.4 (1.3) −1.6 (1.5) <0.0005
  1. Data are presented as mean (SD)
  2. aAs determined by ANOVA across indication for testing