Table 1 Subject characteristics by indication for testing
Indication for testing | Presumed GH sufficient short stature (GH ≥ 10 μg/L) | Possible GHD (GH < 10 μg/L) | Concern for multiple pituitary abnormalities | Neoplasm with risk to pituitary | Exogenous glucocorticoid exposure | Known multiple pituitary abnormalities | p-valuea |
|---|---|---|---|---|---|---|---|
n | 35 | 33 | 52 | 50 | 35 | 17 | - |
Sex (% female) | 34Â % | 27Â % | 29Â % | 16Â % | 34Â % | 29Â % | 0.4 |
Age (years) | 9.1 (4.6) | 8.4 (4.1) | 7.3 (5.0) | 10.1 (3.0) | 8.1 (4.9) | 12.6 4.2) | 0.0002 |
Tanner stage (Breast/Genital) | |||||||
 I | 28 (80 %) | 29 (88 %) | 44 (85 %) | 33 (66 %) | 25 (71 %) | 7 (41 %) | <0.0005 |
 II–IV | 7 (20 %) | 4 (12 %) | 7 (13 %) | 17 (34 %) | 6 (17 %) | 7 (41 %) |  |
 V | 0 | 0 | 1 (2 %) | 0 | 4 (11 %) | 3 (18 %) |  |
Presence of pubic hair | |||||||
 No | 29 (83 %) | 32 (97 %) | 47 (90 %) | 32 (64 %) | 27 (77 %) | 8 (47 %) | <0.0005 |
 Yes | 6 (17 %) | 1 (3 %) | 5 (10 %) | 18 (36 %) | 8 (23 %) | 9 (53 %) |  |
Weight (kg) | 23.6 (11.1) | 24.5 (14.2) | 25.9 (17.4) | 31.8 (13.1) | 31.0 (22.9) | 47.5 (22.4) | <0.0005 |
BMI z-score | −0.50 (0.98) | −0.04 (1.25) | 0.55 (1.12) | 0.27 (1.05) | 0.45 (1.36) | 0.57 (1.53) | 0.0009 |
Height z-score | −2.8 (0.8) | −2.6 (0.9) | −1.8 (1.6) | −1.6 (1.4) | −1.4 (1.3) | −1.6 (1.5) | <0.0005 |