Table 1 Baseline demographic characteristics of Noonan syndrome (NS) and Turner syndrome (TS) patients with complete 4-year longitudinal data (unadjusted data)
Baseline characteristic | NS, mean ± SD | TS, mean ± SD | ||
|---|---|---|---|---|
All patients | GHD subseta | All patients | GHD subseta | |
N, Sex (male:female) | N = 30 (24:6) | n = 8 (7:1) | N = 294 (0:294) | n = 21 |
Age, years (range) | 8.39 ± 3.45 (2.38–14.29) | 8.97 ± 4.19 (2.38–14.04) | 7.81 ± 3.22 (0.51–15.23) | 8.22 ± 3.21 (3.08–14.45) |
HSDS | −2.64 ± 0.96 | −2.61 ± 0.81 | −2.67 ± 0.88 | −2.84 ± 0.53 |
−0.46 ± 0.89 | −0.43 ± 0.85 | 0.30 ± 0.99 | −0.07 ± 0.67 | |
HSDS (Westerlaken) [21] | NA | NA | −0.20 ± 1.01 | −0.53 ± 0.71 |
HSDS (Cabrol) [20] | NA | NA | −0.05 ± 1.03 | −0.39 ± 0.70 |
Target HSDS | −0.43 ± 0.83 | −0.81 ± 0.75 (n = 6) | −0.24 ± 1.02 | −0.56 ± 0.89 |
TH-corrected HSDSc | −2.19 ± 1.14 | −1.70 ± 1.19 (n = 6) | −2.46 ± 1.16 | −2.27 ± 1.10 |
Bone age, years | 6.92 ± 3.58 | 6.96 ± 4.92 (n = 6) | 6.72 ± 3.03 | 7.56 ± 3.12 (n = 12) |
Bone age – chronological age | −1.61 ± 1.22 | −2.08 ± 1.17 (n = 6) | −1.31 ± 1.12 | −1.49 ± 1.07 (n = 12) |
Father’s height (cm) | 176.19 ± 7.38 | 173.78 ± 6.71 (n = 6) | 176.94 ± 7.89 | 172.85 ± 8.05 |
Mother’s height (cm) | 161.53 ± 8.49 | 158.08 ± 4.96 (n = 6) | 163.57 ± 6.96 | 162.18 ± 6.93 |
IGF-I SDS | −1.42 ± 1.45 (n = 19) | −2.52 ± 1.27 (n = 5) | −0.89 ± 1.51 (n = 147) | −1.21 ± 1.28 (n = 11) |