Fig. 1

Flow diagram of article selection. The initial literature search identified 26 articles. Nine articles were excluded because they were not evaluating adult height. An additional 13 articles were excluded because adult height data was not available, not all subjects were treated with growth hormone, or the study included the same cohort as a selected study. ^a = other sources included asking authors in the field if they were working on any current studies in this area and footnote chasing (looking at references of the 26 articles to identify more articles). ^b = 9 studies were excluded because the primary aim was not evaluating final height/near final height, ex. Effect of oxandrolone on glucose metabolism, on voice frequency, on psychological and behavioral characteristics, on body proportions, gonadotropin pulsatility, lipoprotein a, arithmetic learning disability, cognition, and thyroid hormone parameters (reference # 15–23). ^c = 13 studies total were excluded for the following reasons: 3 studies did not have final height or near final height data (ref #12,13,31), in 2 studies not all subjects were treated with GH (ref #7, 11), 7 of the studies involved the same cohort/population as the 4 chosen studies (ref #24-30), and 1 study had no control group on GH only (ref#32)