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Table 2 Sensitivity, specificity, and positive predictive value for tumor markers (n = 26)

From: Association of immunohistochemical markers with premalignancy in Gonadal Dysgenesis

Tumor markers Sensitivity (95 % CI) Specificity (95 % CI) Positive predictive value given prevalence of gonadal malignancy as 15-40 %
OCT 3/4, PLAP, and CD117 combined 100 % (40.2-100 %) 73.9 (51.6-89.7 %) 40.3-71.9 %
OCT 3/4 100 % (40.2-100 %) 52.2 % (30.6-73.1 %) 26.9-58.2 %
PLAP 100 % (40.2-100 %) 73.9 % (51.6-89.7 %) 40.3-71.9 %
Β-catenin 100 % (40.2-100 %) 4.4 % (0.7-22.0 %) 15.6-41.1 %
CD117 100 % (40.2-100 %) 34.8 % (16.4-57.3 %) 21.3-50.6 %
AFP 0 % (0-59.8 %) 95.7 % (78.0-99.3 %) 0 %
  1. Calculations based on the total case number of 26