Table 2 Sensitivity, specificity, and positive predictive value for tumor markers (n = 26)
From: Association of immunohistochemical markers with premalignancy in Gonadal Dysgenesis
Tumor markers | Sensitivity (95 % CI) | Specificity (95 % CI) | Positive predictive value given prevalence of gonadal malignancy as 15-40 % |
|---|---|---|---|
OCT 3/4, PLAP, and CD117 combined | 100 % (40.2-100 %) | 73.9 (51.6-89.7 %) | 40.3-71.9 % |
OCT 3/4 | 100 % (40.2-100 %) | 52.2 % (30.6-73.1 %) | 26.9-58.2 % |
PLAP | 100 % (40.2-100 %) | 73.9 % (51.6-89.7 %) | 40.3-71.9 % |
Β-catenin | 100 % (40.2-100 %) | 4.4 % (0.7-22.0 %) | 15.6-41.1 % |
CD117 | 100 % (40.2-100 %) | 34.8 % (16.4-57.3 %) | 21.3-50.6 % |
AFP | 0 % (0-59.8 %) | 95.7 % (78.0-99.3 %) | 0 % |