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Table 3 Main parameters and effects of of rhGH or rhGH + Anastrazole administration in the 24 adolescent males

From: A randomized pilot trial of growth hormone with anastrozole versus growth hormone alone, starting at the very end of puberty in adolescents with idiopathic short stature

 

GH alone

GH + Anastrazole

P

N

12

12

 

GH dosage (mg/k.d)

0.073 ± 0.09

0.076 ± 0.01

NS

Duration of GH administration (mo)

11.5 ± 5

19 ± 5.9

0.02

Age at end of GH (yrs)

16.2 ± 1.1

16.8 ± 0.7

0.08

Mean IGF1 (SDS)

0.55 ± 0.3

0.65 ± 0.6

NS

Delta IGF1 (SDS)*

1.02 ± 0.3

0.97 ± 0.5

NS

Predicted height**

   

 cm

158.2 ± 2.9

157.9 ± 3.8

NS

 SDS

- 2.84 ± 0.5

- 2.9 ± 0.6

NS

Final height

   

 cm

164.2 ± 5.6

168.4 ± 2.6

0.02

 SDS

- 1.8 ± 0.9

- 1.1 ± 0.4

0.02

Growth velocity Year 1 (cm/yr)

4.9 ± 4

6.7 ± 2.8

0.18

Growth velocity Year 2 (cm/yr)

1.2 ± 0.5

3.6 ± 2.7

0.008

Height increase from GH onset (HtG1) (cm)

7.8 ± 5

12.7 ± 5.6

0.02

Height gain vs PAH (HtG2) (cm)

5.9 ± 4.5

10.5 ± 5.2

0.02

  1. Values are expressed as mean ± SD.
  2. *Mean IGF1 during GH-IGF1 at onset of GH.
  3. **see Methods/Calculation.