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Table 2 Characteristics of the growth curve of the 24 adolescent males at onset of rhGH or rhGH + Anastrazole administration

From: A randomized pilot trial of growth hormone with anastrozole versus growth hormone alone, starting at the very end of puberty in adolescents with idiopathic short stature

  GH alone GH + Anastrazole Historical controls
N 12 12 17
Age at take-off of growth (yrs) 12.3 ± 1.2 12.3 ± 0.9 12.2 ± 1.5
Height at take-off of growth    
 cm 139.7 ± 4 139.7 ± 3 140 ± 5
 SDS - 1.2 ± 0.7 - 1.5 ± 0.9 −1.2 ± 0.9
Age at peak velocity (yrs) 14.3 ± 1 14.2 ± 0.7 14.3 ± 1.2
Height at peak velocity (HPV)    
 cm 154.1 ± 4 153.6 ± 5 154 ± 6
 SDS - 1.3 ± 1 - 1.1 ± 0.8 −1.3 ± 1.1
Time interval between PGV and GH onset (mo)*a 0.9 ± 0.6 1 ± 0.5 1 ± 0.7**
Growth velocity between PGV and GH onset    
 cm/yr 2 ± 1 2.3 ± 0.7 2.2 ± 0.8**
 SDS - 2.6 ± 1.4 - 3 ± 1.7 −2.8 ± 1.9**
  1. We observed no significant differences between the groups. Values are expressed as mean ± SD.
  2. a*see Methods.
  3. **mean age at GH onset in the GH treated adolescents was used to calculate corresponding values for time interval and growth velocity in the historical controls.