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Table 1 Baseline characteristics of patients with CPP and EP

From: Higher prevalence of obesity and overweight without an adverse metabolic profile in girls with central precocious puberty compared to girls with early puberty, regardless of GnRH analogue treatment

  CPP EP p value
n 37 34 -
Treated/Untreated 29/8 14/20 -
Clinical characteristics    -
Chronological age (yr) 7.4 ± 1.3 8.8 ± 0.6 0.001
Bone age (yr) 8.7 ± 2.1 9.3 ± 1.3 NS
Weight (Kg) 32.1 ± 6.7 32.6 ± 4.4 NS
Weight (z-score) 1.4 ± 0.8 1.9 ± 1.2 0.001
Height (SDS) 2.8 ± 1.2 1.3 ± 1.1 0.001
BMI (Kg/m2) 18.8 ± 2.4 18.2 ± 2 NS
BMI (z-score) 1.1 ± 0.8 0.6 ± 0.7 0.004
Obesity/Overweight n(%) 27 (72.9) 12 (35.3) 0.001
Obesity n(%) 9 (24.3) 3 (8.8) NS
Overweight n(%) 18 (48.6) 9 (26.5) 0.054
Predict adult height (SDS) (SDS) (SDS) 0.3 ± 2.3 1.5 ± 1.2 0.04
Height velocity (SDS) 1.6 ± 2.1 1.8 ± 1.8 NS
Hormonal evaluation    
DHEAS (ng/ml) 51.1 ± 34.2 52.8 ± 23.7 NS
LH peak (IU/L) 10.9 ± 7.3 6.1 ± 4.5 0.01
LH to FSH stimulated ratio 1.1 ± 0.7 1.1 ± 1.7 NS
Estradiol (pg/ml) 22.3 ± 17 14 ± 11.8 0.01
Ovarian volume (ml) 1.7 ± 0.7 1.8 ± 0.5 NS
Uterine length (cm) 3.7 ± 1.2 3.4 ± 1 NS
Metabolic profile    
Fasting glucose (mg/dl) 73.3 ± 8.5 80.2 ± 10.2 0.04
Total Cholesterol (mg/dl) 158.6 ± 31.9 185.6 ± 35.7 0.02
LDL-C (mg/dl) 97 ± 35.1 113.2 ± 17.6 NS
HDL-C (mg/dl) 45 ± 8.9 53 ± 9.1 NS
TGR (mg/dl) 89.8 ± 46.7 104.8 ± 48.8 NS
TGR/HDL-C ratio 2.2 ± 0.9 1.5 ± 0.5 NS
  1. Data are displayed as mean (± SDS). BMI, body mass index; DHEAS, dehydroepiandrosterone sulfate; LH, luteinizing hormone; FSH, follicle-stimulating hormone; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TGR, Triglycerides.