Table 2 Malignancy risk based upon type of gonadal dysgenesis, location of gonad, gross pathology, and immunohistochemistry
From: State of the art review in gonadal dysgenesis: challenges in diagnosis and management
| Â | Low risk | Intermediate risk | High risk |
|---|---|---|---|
Degree of virilization | Normally virilized males | Mild undervirilization | Ambiguous genitalia |
Location of gonad | Scrotal gonad with normal appearance | Inguinal gonad | Abdominal gonad |
Gross pathology | -Streak gonad without germ cells | Dysgenetic testicle that is OCT 3/4 positive with intermediate risk criteria | -Undifferentiated gonadal tissue |
-Ovary | |||
- Testicle (OCT 3/4 negative) | |||
- Dysgenetic testicle that is OCT 3/4 negative | -Dysgenetic testicle that is OCT 3/4 positive with high risk criteria | ||
Immunohistochemistry | OCT 3/4 negative | OCT 3/4 positive cells located luminally, scattered within the whole gonad, TSPY negative or weakly positive, SCF negative, age < 1 year. | OCT 3/4 positive cells located in the basal lamina, focal location, TSPY strongly positive, SCF positive, age > 1 year. |