Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

Table 9 Comparison of Our Results with Published Adult Heights of Controls & Treated Children

			AH Controls #305	AH Treated #212	Difference		Benefit
Published Study [Ref. #]	Number	mg/kg/wk	Mean SDS	Mean SDS	Mean SDS		Males cm	Females cm
Lopez-Siguero et al. [4]	35	0.16 to 0.25	-2.03	-1.31	0.72		4.86	NA
Coutant et al. [5]	32	0.16	-2.08	-2.10	-0.02		-0.13	-0.12
Lopez-Siguero et al. [6]	20	0.16 to 0.25	-2.01	-1.46	0.55		3.71	NA
Leschek et al.* [1]	22	0.22	-2.34	-1.77	0.57		3.84	3.50
Hindmarsh et al. [7]	16	0.16 to 0.28	-1.88	-1.33	0.55		3.71	3.38
Buchlis et al. [8]	36	0.3	-2.10	-1.50	0.60	0.4 M 1.2 F	3.00	6.8
Albertsson-Wikland et al.* [3]	31	0.47	-2.20	-1.50	0.70		5.0	4.30
McCaughey et al.* [2]	8	0.35 0.4 to 0.31	-2.37	-1.14	1.23		NA	7.55
Wit et al. [9]	12	0.32 0.32 to 0.26	-2.40	-1.30	1.10		7.42	6.75
Total number	212
Mean	23.6		-2.16	-1.49	0.67		3.92	4.83
Minimum	8		-2.40	-2.10	-0.02		-0.13	-0.12
Maximum	36		-1.88	-1.14	1.23		7.42	7.55
*Our study treated*	88	*0.32 (0.03)*	*(-2.16) (Historical)*	*-0.71*	*1.45*		*9.8*	*8.9*
*Difference*
*Mean*				*+0.78*	*+0.78*		*5.2*	*4.8*
*Minimum*				*+0.43*	*+0.22*		*1.5*	*1.35*
*Maximum*				*+1.39*	*+1.47*		*9.9*	*9.0*

ISSN: 1687-9856