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Table 8 Baseline, Adult height, & Adult height Gain of controls (Mean SDS & 95% CI) in Published studies and of Treated Children in Our Study

From: Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

 

Baseline

Adult height

Adult height gain

Published study [Ref. #]

Number

Mean SDS

(95% CI)

Mean SDS

(95% CI)

Mean SDS

(95% CI)

Lopez-Siguero et al. [4]

42

-2.40

-2.52 – -2.28

-2.03

-2.25 – -1.81

0.37

0.37 – 0.80

Coutant et al. [5]

51

-2.74

-2.92 – -2.56

-2.08

-2.36 – -1.80

0.66

0.66 – 0.89

Lopez-Siguero et al. [6]

44

-2.38

-2.50 – -2.26

-2.01

-2.22 – -1.80

0.37

0.37 – 0.60

Leschek et al.* [1]

11

-2.80

-3.20 – -2.40

-2.34

-2.72 – -1.96

0.46

0.46 – 0.23

Hindmarsh et al. [7]

10

-2.34

-2.78 – -1.90

-1.88

-2.29 – -1.47

0.46

0.46 – 0.60

Buchlis et al. [8]

58

-2.90

-3.08 – -2.72

-2.10

-2.36 – -1.84

0.80

0.80 – 0.80

Albertsson-Wikland et al.* [3]

19

-2.76

-2.95 – -2.57

-2.20

-2.56 – -1.84

0.40

0.40 – 0.62

McCaughey et al.* [2]

6

-2.55

-2.89 – -2.21

-2.37

-2.85 – -1.89

0.18

0.18 – 0.40

Wit et al. [9]

64

-3.10

-3.22 – -2.98

-2.40

-2.60 – -2.20

0.70

0.70 – 0.60

Total

305

      

Mean

34

-2.66

 

-2.16

 

0.49

 

Minimum

6

-3.00

 

-2.40

 

0.18

 

Maximum

64

-2.34

 

-1.88

 

0.80

 

Our study (treated)

88

-2.61

-2.74 – -2.48

-0.71

-0.87 – -0.55

1.90

1.74 – 2.06

Difference

    

cm

 

cm

M

F

M

F

Mean

 

+0.05

 

+1.45

9.8

8.9

+1.41

9.5

8.6

Minimum

 

-0.27

 

+1.17

7.9

7.1

+1.10

7.4

6.7

Maximum

 

+0.39

 

+1.69

11.4

10.3

+1.72

11.6

10.5

  1. *Randomized controlled trials; M = male; F = Female; [#] reference number.