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Table 8 Baseline, Adult height, & Adult height Gain of controls (Mean SDS & 95% CI) in Published studies and of Treated Children in Our Study

From: Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

  Baseline Adult height Adult height gain
Published study [Ref. #] Number Mean SDS (95% CI) Mean SDS (95% CI) Mean SDS (95% CI)
Lopez-Siguero et al. [4] 42 -2.40 -2.52 – -2.28 -2.03 -2.25 – -1.81 0.37 0.37 – 0.80
Coutant et al. [5] 51 -2.74 -2.92 – -2.56 -2.08 -2.36 – -1.80 0.66 0.66 – 0.89
Lopez-Siguero et al. [6] 44 -2.38 -2.50 – -2.26 -2.01 -2.22 – -1.80 0.37 0.37 – 0.60
Leschek et al.* [1] 11 -2.80 -3.20 – -2.40 -2.34 -2.72 – -1.96 0.46 0.46 – 0.23
Hindmarsh et al. [7] 10 -2.34 -2.78 – -1.90 -1.88 -2.29 – -1.47 0.46 0.46 – 0.60
Buchlis et al. [8] 58 -2.90 -3.08 – -2.72 -2.10 -2.36 – -1.84 0.80 0.80 – 0.80
Albertsson-Wikland et al.* [3] 19 -2.76 -2.95 – -2.57 -2.20 -2.56 – -1.84 0.40 0.40 – 0.62
McCaughey et al.* [2] 6 -2.55 -2.89 – -2.21 -2.37 -2.85 – -1.89 0.18 0.18 – 0.40
Wit et al. [9] 64 -3.10 -3.22 – -2.98 -2.40 -2.60 – -2.20 0.70 0.70 – 0.60
Total 305       
Mean 34 -2.66   -2.16   0.49  
Minimum 6 -3.00   -2.40   0.18  
Maximum 64 -2.34   -1.88   0.80  
Our study (treated) 88 -2.61 -2.74 – -2.48 -0.71 -0.87 – -0.55 1.90 1.74 – 2.06
Difference      cm   cm
M F M F
Mean   +0.05   +1.45 9.8 8.9 +1.41 9.5 8.6
Minimum   -0.27   +1.17 7.9 7.1 +1.10 7.4 6.7
Maximum   +0.39   +1.69 11.4 10.3 +1.72 11.6 10.5
  1. *Randomized controlled trials; M = male; F = Female; [#] reference number.