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Table 5 Effect of Age on Treated Children with ISS

From: Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

Mean (SD) [min to max]

Number

Treatment start age (yrs)

Stop age (yrs)

Baseline height SDS (SD)

Adult height SDS (SD)

Adult height gain SDS (SD)

Males – NFSS

Normal puberty

20

8.6 (2.76) [5.0 to 13.4]

16.4 (0.97) [14.7 to 18.3]

-2.53 (0.47) [-3.76 to -1.98]

-0.60 (0.67) [-1.73 to 0.81]

1.94 (0.60) [0.94 to 3.01]

Delayed puberty

27

14.4 (1.10) [12.4 to 16.3]

17.9 (0.84) [16.0 to 19.4]

-2.60 (0.34) [-3.37 to -2.00]

-0.49 (0.61) [-1.36 to 1.13]

2.11 (0.66) [1.30 to 3.91]

  

p <0.001

 

p, 0.601

p, 0.603

p, 0.372

Males – FSS

Normal puberty

12

10.3 (2.47) [4.7 to 13.7]

16.9 (0.77) [15.7 to 18.1]

-2.65 (0.83) [-4.51 to -1.98]

-1.19 (0.79) [-2.20 to 0.22]

1.46 (0.68) [0.29 to 2.40]

Delayed puberty

9

14.1 (1.31) [11.6 to 15.9]

17.6 (0.65) [16.9 to 18.7]

-2.51 (0.49) [-3.26 to -1.96]

-1.07 (0.62) [-2.20 to 0.24]

1.44 (0.52) [0.86 to 2.20]

  

p <0.001

 

p, 0.669

p, 0.729

p, 0.949

Females – NFSS

Normal puberty

13

11.4 (1.21) [9.6 to 13.3]

15.5 (0.81) [13.5 to 16.7]

-2.80 (1.04) [-5.20 to -1.81]

-0.77 (0.57) [-1.84 to 0.09]

2.03 (0.88) [1.04 to 4.13]

  1. Abbreviations: min minimum, max maximum.