Skip to main content

Advertisement

Table 5 Effect of Age on Treated Children with ISS

From: Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

Mean (SD) [min to max] Number Treatment start age (yrs) Stop age (yrs) Baseline height SDS (SD) Adult height SDS (SD) Adult height gain SDS (SD)
Males – NFSS
Normal puberty 20 8.6 (2.76) [5.0 to 13.4] 16.4 (0.97) [14.7 to 18.3] -2.53 (0.47) [-3.76 to -1.98] -0.60 (0.67) [-1.73 to 0.81] 1.94 (0.60) [0.94 to 3.01]
Delayed puberty 27 14.4 (1.10) [12.4 to 16.3] 17.9 (0.84) [16.0 to 19.4] -2.60 (0.34) [-3.37 to -2.00] -0.49 (0.61) [-1.36 to 1.13] 2.11 (0.66) [1.30 to 3.91]
   p <0.001   p, 0.601 p, 0.603 p, 0.372
Males – FSS
Normal puberty 12 10.3 (2.47) [4.7 to 13.7] 16.9 (0.77) [15.7 to 18.1] -2.65 (0.83) [-4.51 to -1.98] -1.19 (0.79) [-2.20 to 0.22] 1.46 (0.68) [0.29 to 2.40]
Delayed puberty 9 14.1 (1.31) [11.6 to 15.9] 17.6 (0.65) [16.9 to 18.7] -2.51 (0.49) [-3.26 to -1.96] -1.07 (0.62) [-2.20 to 0.24] 1.44 (0.52) [0.86 to 2.20]
   p <0.001   p, 0.669 p, 0.729 p, 0.949
Females – NFSS
Normal puberty 13 11.4 (1.21) [9.6 to 13.3] 15.5 (0.81) [13.5 to 16.7] -2.80 (1.04) [-5.20 to -1.81] -0.77 (0.57) [-1.84 to 0.09] 2.03 (0.88) [1.04 to 4.13]
  1. Abbreviations: min minimum, max maximum.