Table 3 Treatment parameters at maximum estrogen dose (18 Months) (Mean ± SE)

Weight (kg)

53.8 ± 10.1

43.6 ± 4

40.6 ± 3.1

Change in Weight from baseline (kg)

5.9 ± 0.7

7.1 ± 1.6

7.2 ± 0.8

Height (cm)

153.2 ± 2.9

147.6 ± 3.9

148.6 ± 3.5

Change in Height from baseline (cm)

6.3 ± 1.3

8.1 ± 1.3

8.2 ± 1.7

Estradiol (pg/mL)

14 ± 5^a

12 ± 5

53 ± 19^a,b

Estrone (pg/mL)

57.7 ± 22.6^a

53.4 ± 28

26 ± 4^a

Estrone Sulfate (ng/dL)

209 ± 68.1^a

364.8 ± 153^a

72 ± 27.9^a

FSH (mIU/mL)

30 ± 9.4

88 ± 25.6

29 ± 26.4

LH (mIU/mL)

29 ± 14.5

44 ± 13.7^a

4.8 ± 3.7

SHBG (nmol/L)

130 ± 38.3

35.5 ± 7.4

59 ± 20.2

HS-CRP (mg/L)

6.27 ± 4

0.5 ± 0.2

0.1 ± 0.03

Fibrinogen Activity (mg/dL)

347 ± 59.8

284 ± 20.2

205 ± 38.9

Antithrombin Activity (%)

109 ± 3.2

121 ± 5.4

102 ± 5

Glucose (mg/dL)

82 ± 5.5

83 ± 3.8

82 ± 0

Insulin (uIU/mL)

19.6 ± 12.8

5.5 ± 1.2

3.9 ± 0.7

AST (U/L)

47 ± 13.6

24 ± 3.3

19 ± 1.2

ALT (U/L)

55 ± 26.6

23 ± 5.3

15 ± 3.5

Cholesterol (mg/dL)

177 ± 18.7

160 ± 0.6

155 ± 19.1

Triglycerides (mg/dL)

195 ± 72.4

126 ± 42.3

62 ± 5.5

HDL (mg/dL)

54 ± 5.1

49 ± 6

54 ± 10.7

LDL (mg/dL)

95 ± 11.2

91 ± 5.8

85 ± 11.3

Plasma Renin (ng/dL/h)

313 ± 83

178 ± 46

243 ± 103.5

IGFBP-3 (mg/L)

2.9 ± 0.4

3.6 ± 0.4

3.2 ± 0.1

IGF-1 (ng/mL)

266 ± 73.1

482 ± 73.6

355 ± 71