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Table 3 Transition from hydrochlorothiazide to oral desmopressin

From: Efficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy

S

Etiology

Age of transition

Reason for transition

Dose of desmopressin

F/U: growth

(oral)

1

SOD

12 months

Failure to thrive

50 mcg BD

Improved growth

10.5 mcg/kg/

2

SOD

3 months

Acute gastroenteritis with low K; difficulty in maintaining Na

25 mcg BD

-NA*-

4.5 mcg/kg/day

3

SOD

6 months

Failure to thrive

10 mcg BD

No improvement in growth; concerns regarding compliance

3.3 mcg/kg/day

4

HPE

12 months

Failure to thrive

50 mcg BD

No improvement in growth but growth impaired due to underlying condition

Hypernatremia

10 mcg/kg/day

  1. *NA: not available.
  2. SOD: Septo-optic dysplasia.
  3. HPE: Holoprosencephaly.