United States multicenter study of factors predicting the persistence of GH deficiency during the transition period between childhood and adulthood

Table 2 Predictors of persistent GH deficiency: all patients (n = 73)

	History of organic disease	≥2 extra PHDs	≥1 extra PHD	IGF-I < -5.3 SDS	IGF-I < -3.0 SDS	IGF-I < -2.0 SDS	≥1 extra PHD and IGF-I < -2.0 SDS	IGFBP-3 < -2.0 SDS
Positive Predictive Value (%)	100	100	96	100	84	65	100	100
Negative Predictive Value (%)	64	66	76	71	83	84	75	59
Specificity (%)	100	100	97	100	83	46	100	100
Sensitivity (%)	47	53	71	63	84	92	68	37

Abbreviations: IGF-I = insulin-like growth factor I, IGFBP-3 = insulin-like growth factor binding protein 3, n = number, PHD = pituitary hormone deficiency, SDS = standard deviation score.

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