Figure 1

Scattergram of unstimulated versus peak GnRHa-stimulated LH levels during the histrelin implant therapy. Data from all follow-up visits (n = 308) during the first year of histrelin implant therapy (open circles) and the second through fifth year of therapy (solid circles) are shown. The horizontal dashed line represents the a priori peak GnRHa-stimulated LH threshold level of 4 mIU/mL defining adequate suppression. The vertical dashed line indicates the published 0.3 mIU/mL pubertal threshold for unstimulated LH levels [15].