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Table 3 Proposed criteria for unbiased genetic studies in ISS

From: Towards identification of molecular mechanisms of short stature

Severe short stature, height < -3 SDS for CNV, <-4 SDS for whole exome sequencing;
Disproportionate short stature within family, height < -2 SDS from midparental target height;
Height < -2 SDS AND major congenital abnormalities or neurocognitive disorder;
Short stature segregating within the family in a dominant pattern;
History of consanguinity