Table 2 Studies on Adrenal function in Prader-Willi syndrome
From: Endocrine manifestations and management of Prader-Willi syndrome
Study | N | Mean age, range (years) | Test | % Insufficient | Comment |
|---|---|---|---|---|---|
De Lind van Wijingaarden 2008 [63] | 25 | 9.7 (3.7-18.6), median | Overnight Single-dose Metyrapone | 60 | Baseline salivary cortisol levels not significantly different in sufficient versus insufficient |
Grugni 2013 [64] | 53 | 27.9 (18–45.2) | LDSST | 15.1 |  |
Corrias 2012 [65] | 84 | 7.7 (0.8-17.9) | LDTST | 14.2 | Lower cortisol peak with deletion subtype versus UPD |
Connell 2010 [66] | 25 | 7.2 (0.43-16.3) | ITT (15), HDSST (10), LDSST (4) | 4 | 1 subject tested insufficiency by ITT |
Nyunt 2010 [67] | 41 | 7.7 | LDSST | 0 | Â |
Farholt 2011 [68] | 57 | 22 (0.58-48) | HDST | 0 | Â |
Farholt 2011 [68] | 8 | 25 (16–33) | ITT | 0 |  |