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Table 2 Studies on Adrenal function in Prader-Willi syndrome

From: Endocrine manifestations and management of Prader-Willi syndrome

Study N Mean age, range (years) Test % Insufficient Comment
De Lind van Wijingaarden 2008 [63] 25 9.7 (3.7-18.6), median Overnight Single-dose Metyrapone 60 Baseline salivary cortisol levels not significantly different in sufficient versus insufficient
Grugni 2013 [64] 53 27.9 (18–45.2) LDSST 15.1  
Corrias 2012 [65] 84 7.7 (0.8-17.9) LDTST 14.2 Lower cortisol peak with deletion subtype versus UPD
Connell 2010 [66] 25 7.2 (0.43-16.3) ITT (15), HDSST (10), LDSST (4) 4 1 subject tested insufficiency by ITT
Nyunt 2010 [67] 41 7.7 LDSST 0  
Farholt 2011 [68] 57 22 (0.58-48) HDST 0  
Farholt 2011 [68] 8 25 (16–33) ITT 0  
  1. LDSST = low-dose short Synacthen test (1 μg).
  2. LDTST = low-dose tetracosactrin stimulation test (1 μg).
  3. HDSST = high-dose short Synacthen test (250 μg).
  4. UPD = uniparental disomy.
  5. HDST = high-dose Synacthen test (250 μg).
  6. ITT – insulin tolerance test (0.15 units/kg).