Figure 6From: Molecular diagnostic testing for Klinefelter syndrome and other male sex chromosome aneuploidiesReceiver operator characteristic curves for detection of 48,XXYY syndrome. The average and median of the four XA marker data points for each sample was calculated: either the average, median or individual marker data was compared to the threshold for detecting 48,XXYY syndrome. The threshold was varied by 1% increments from 33-52% X allele signal. The sensitivity (TP/(TPā+āFN)) and false positive rate (FP/(FPā+āTN)) were calculated for each value of the appropriate threshold. True positives (TP) have a 48,XXYY karyotype and X allele signal greater than the threshold; false negatives (FN) have the same karyotype and X allele signal less than or equal to the threshold. True negatives (TN) have a 46,XY karyotype and X allele signal less than or equal to the threshold; false positives (FP) have a 46,XY karyotype and X allele signal above the threshold.Back to article page