Risk factors for cardiovascular disease and type 2 diabetes retained from childhood to adulthood predict adult outcomes: the Princeton LRC Follow-up Study

Table 3 Childhood (LRC) and adulthood (PFS) predictors for cardiovascular disease (CVD), type 2 diabetes (T2DM) and impaired fasting glucose (IFG) at PFS

Young adult outcome	Childhood Predictors	p	Odds Ratio, 95% Confidence Intervals
CVD (19 Yes, 751 no) ^a 770 observations used AUC = 0.843	TG at LRC and PFS (high to high vs others)	.0005	6.06, 2.20–16.7
	Age at PFS (year)	.0009	1.30, 1.11–1.53
	BMI at LRC and PFS (low to low vs others)	.019	0.25, 0.077–0.79
T2DM (29 Yes, 417 normal) ^b 446 observations used AUC = 0.842	BP at LRC and PFS (high to high vs others)	.0006	6.74, 2.26–20.07
	TG at LRC and PFS (high to high vs others)	.0026	4.95, 1.75–14.06
	BMI at PFS (high vs not high)	.0010	4.56, 1.85–11.23
	Glucose at LRC (high vs not high)	.0057	5.93, 1.68–20.95
	Age at PFS	.0016	1.26, 1.09–1.45
	Black race	.043	2.53, 1.03–6.24
IFG (88 Yes, 617 normal) ^b 705 observations used AUC = 0.699	BP at PFS (high vs not high)	<.0001	2.63, 1.64–4.23
	TG at PFS (high vs not high)	.0009	2.24, 1.39–3.60
	Cigarette smoking (yes vs no)	.018	1.78, 1.10–2.89

^a Logistic regression model fit after stepwise selection (SLE = .15, SLS = .05) from categorical explanatory variables: race, risk factors at LRC and at PFS (TG, HDLC, LDLC, BMI, BP and glucose), changes of risk factors from LRC to PFS (TG, HDLC, LDLC, BMI, BP and glucose), cigarette smoking (yes/no), parents had CVD (yes/no), parents had CVD before age 50 (yes/no), and parents had CVD before age 60 (yes/no), and age at PFS.
^b Logistic regression model fit after stepwise selection (SLE = .15, SLS = .05) from categorical explanatory variables: race, risk factors at LRC (TG, HDLC, LDLC, BMI, BP and glucose), risk factors at PFS (TG, HDLC, LDLC and BMI), changes of risk factors from LRC to PFS (TG, HDLC, LDLC, BMI and BP), cigarette smoking (yes/no), parents had T2DM (yes/no), and age at PFS.

ISSN: 1687-9856