Genetic factors associated with small for gestational age birth and the use of human growth hormone in treating the disorder

Table 6 Use of hGH therapy in SGA children in the United States and Europe

	FDA-approved indication in 2001	EMEA-approved indication in 2003
Age at start of treatment (year)	2	4
Height SDS at start	Not stated	−2.5 SD
Growth velocity before treatment	No catch-up growth	Less than 0 SD for age
Reference to midparental height	Not stated	Height SDS > 1 SD below midparental height SDS
Dose (mcg/kg/day)	70	35

FDA, United States Food and Drug Administration; EMEA, European Agency for the Evaluation of Medicinal Products; hGH, human growth hormone; SDS, standard deviation score; SGA, small for gestational age.
Reprinted with permission from [1].

ISSN: 1687-9856