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Table 2 Characteristics at background, GH start, and 1st year on GH

From: Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia

 

ONH/SOD

Non-ONH/SOD

 

N

Median

10th, 90th percentiles

N

Median

10th, 90th percentiles

P-value

 

Background

     

Gender, males

395

227 (57.5%)

 

158

101 (63.9%)

  

Birth Length SDS

206

0.27

-1.3, 2.0

104

-0.62

-2.5, 1.2

< 0.001

Birth Weight SDS

349

-0.31

-1.7, 1.1

133

-0.58

-2.0, 1.0

0.021

Mid-Parental Height SDS

324

-0.23

-1.8, 1.3

140

-1.04

-3.0, 0.5

< 0.001

Peak GH (μg/L)

307

2.60

0.8, 7.2

131

3.30

0.5, 10.8

0.053

Other Pituitary Hormone Deficiencies

395

287 (72.7%)

 

158

82 (51.9%)

 

< 0.001

   Hypothyroidism

395

250 (63.3%)

 

158

74 (46.8%)

 

< 0.001

   Glucocorticoid deficiency

395

206 (52.2%)

 

158

46 (29.1%)

 

< 0.001

   Diabetes insipidus

395

51 (12.9%)

 

158

6 (3.8%)

 

< 0.001

 

At GH Start

    

Age (years)

395

3.99

0.9, 9.8

158

4.47

0.7, 10.7

0.498

Bone Age (years)

77

3.50

1.4, 8.7

41

4.00

1.2, 10.0

0.784

Height SDS

395

-3.00

-4.8, -0.9

158

-3.68

-6.7, -1.9

< 0.001

Height - Mid-Parental Height SDS

324

-2.74

-4.67, -0.62

140

-2.42

-4.94, -0.72

0.305

Height Velocity (cm/year)

147

5.46

2.35, 12.07

45

5.23

3.19, 9.76

0.904

Weight SDS

395

-1.56

-4.2, 0.5

158

-2.56

-5.7, -0.6

< 0.001

BMI SDS

395

0.22

-1.8, 2.1

158

-0.18

-2.1, 1.6

0.001

GH Dose (mg/kg/week)

395

0.24

0.16, 0.33

158

0.22

0.16, 0.39

0.395

 

1st yr on GH

     

Age (years)

395

5.01

1.87, 10.74

158

5.46

1.64, 11.75

0.500

Bone Age (years)

96

4.40

2.00, 9.00

53

4.17

2.00, 11.5

0.429

Height SDS

395

-1.95

-4.0, 0.0

158

-2.37

-4.7, -0.9

< 0.001

Δ Height SDS

395

1.02

0.0, 2.0

158

1.10

0.3, 2.7

0.066

Height - Mid-Parental Height SDS

324

-1.70

-3.78, 0.29

140

-1.29

-3.15, 0.23

0.010

Height Velocity (cm/year)

395

11.25

6.74, 16.18

158

10.54

6.98, 18.97

0.863

Weight SDS

393

-0.91

-3.3, 1.3

158

-1.81

-3.9, -0.0

< 0.001

BMI SDS

393

0.05

-1.8, 2.3

158

-0.43

-2.1, 1.2

< 0.001

GH Dose (mg/kg/week)

388

0.23

0.14, 0.33

156

0.21

0.13, 0.33

0.068

 

IGHD Prediction Model (Without GH Peak) at 1 year

Predicted Height Velocity

186

10.69

9.03, 12.51

73

9.99

8.28, 11.86

< 0.001

Actual Height Velocity (cm/year)

186

10.72

6.66, 14.37

73

9.49

7.16, 13.77

0.305

Studentized Residual

186

-0.11

-2.53, 1.98

73

-0.04

-1.61, 1.95

0.565

  1. SDS, standard deviation score; GH, growth hormone
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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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