Metabolic control and bone health in adolescents with type 1 diabetes

Table 3 Association between HbA1c and bone mineral density measurements, components of the IGF system, bone turnover markers, and dietary intake of calcium and vitamin D

	Spearman correlation coefficient	p value*	Adjusted p value **
Age	0.24	0.08
Lumbar Spine BMD †	-0.12	0.37	0.63
Volumetric Lumbar Spine † (BMAD)	-0.041	0.76	0.85
Femoral neck BMD †	-0.056	0.68	0.24
Total body BMD †	-0.086	0.53	0.87
% Body fat	0.30	0.02	0.66
IGF-I (ng/ml)	-0.15	0.27	0.92
IGFBP3 (μg/L)	0.13	0.37	0.33
IGFBP4 (μg/L)	0.23	0.10	0.1
IGFBP5 (μg/L)	-0.09	0.52	0.65
NTX (nM BCE/mM creat)	-0.36	0.01	0.73
Bone-specific alkaline phosphatase (μg/L)	-0.26	0.06	0.81
Intact PTH (ρg/ml)	-0.28	0.04	0.2
Serum 25-hydroxyvitamin D (ng/ml)	-0.047	0.74	0.89
Serum Calcium (ml/dL)	0.15	0.28	0.19
Serum Phosphorus (mg/dL)	0.2	0.14	0.01
Serum creatinine (mg/dL)	-0.27	0.04	0.007
UCa/uCr	0.27	0.047	0.05
uPhos/uCr	0.22	0.1	0.37
Average vitamin D intake/day (IU)	-0.09	0.67	0.55
Average calcium intake/day (mg)	-0.13	0.55	0.42

Items in bold p < 0.05.
*Spearman correlation coefficient p value; ** p value adjusted for age, race, and gender; † z-scores

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