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Table 2 Indications for DNA testing

From: Prader-Willi syndrome: A primer for clinicians

Age at assessment Features sufficient to prompt DNA testing
Birth to 2 yr Hypotonia with poor suck
2-6 yr Hypotonia with a history of poor suck
  Global developmental delay
  Short stature and/or growth failure associated with accelerated weight gain
6-12 yr Hypotonia with a history of poor suck (hypotonia often persists)
  Global developmental delay
  Excessive eating (hyperphagia, obsession with food) with central obesity if uncontrolled
  Short stature and/or decreased growth velocity*
13 yr through adulthood Cognitive impairment, usually mild mental retardation
  Excessive eating (hyperphagia, obsession with food) with central obesity if uncontrolled
  Short stature and/or decreased growth velocity*
  Hypothalamic hypogonadism and/or typical behavior problems (including temper tantrums and obsessive-compulsive features)
  1. *Features added by the authors