Table 2 Indications for DNA testing

Birth to 2 yr

Hypotonia with poor suck

2-6 yr

Hypotonia with a history of poor suck

Global developmental delay

Short stature and/or growth failure associated with accelerated weight gain

6-12 yr

Hypotonia with a history of poor suck (hypotonia often persists)

Global developmental delay

Excessive eating (hyperphagia, obsession with food) with central obesity if uncontrolled

Short stature and/or decreased growth velocity*

13 yr through adulthood

Cognitive impairment, usually mild mental retardation

Excessive eating (hyperphagia, obsession with food) with central obesity if uncontrolled

Short stature and/or decreased growth velocity*

Hypothalamic hypogonadism and/or typical behavior problems (including temper tantrums and obsessive-compulsive features)