Figure 1
Association of serum Na levels with (1) GC dosing and then (2) DDAVP administration over time. The effect of stress HC dosing and DDAVP on serum Na levels in a patient with SOD. As shown on the y axis, serum Na (levels mmol/L, □) rise on each occasion in which HC dosing is increased over maintenance dosing (*), consistent with an unmasking of DI in child with partial hypopituitarism over time ( x axis). Note that during a prolonged afebrile period and maintenance dosing, serum Na levels remained in the normal range (pink bar). In this patient, the transient DI during febrile episodes and GC stress dosing was then followed by progression to permanent DI with serum Na of 163 mmol/L, USG of 1.005, and an AVP level of <0.6 pg/mL, and patient was then maintained on DDAVP. Please note that the DDAVP doses were intranasal (IN) preparations given orally, so the effective DDAVP dose is 1/10 of the listed dose.