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Table 2 Biochemical measures at baseline and after 6 months of treatment (mean ± SD).

From: Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy

Test

Initial

Final

Fasting TG (mmol/L)

1.97 ± 1.05

1.96 ± 0.63

HDL (mmol/L)

1.00 ± 0.30

0.93 ± 0.41

LDL (mmol/L)

2.18 ± 0.94

2.43 ± 0.91

Total cholesterol (mmol/L)

4.07 ± 0.81

4.26 ± 0.90

WBISI

2.2 ± 1.1

5.7 ± 8.1

AUCins (pmol/L)

2078.8 ± 668.8

1438.3 ± 988.5

Adiponectin (mg/mL)

10.01 ± 4.39

8.17 ± 3.46

Leptin (ng/mL)

27.64 ± 22.14

23.55 ± 25.34

HbA1c (%)

5.0 ± 0.3

4.8 ± 0.5

AST (U/L)

31.0 ± 6.95

30.4 ± 16.80

ALT (U/L)

28.3 ± 7.45

40.4 ±48.79

Fasting glucose (mmol/L)

4.4 ± 3.60

4.7 ± 0.69

Fasting insulin (pmol/L)

174.3 ± 87.79

130.2 ± 99.56

2 hour glucose (mmol/L)

5.4 ± 0.96

6.2 ± 1.36

2 hour insulin (pmol/L)

995.3 ± 531.19

735.0 ± 683.97

  1. P value: not significant for all variables shown above. TG: triglycerides; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; WBISI: whole body insulin sensitivity index; AUCins: area-under-the-curve insulin; HbA1c: hemoglobin A1c; AST: aspartate aminotransferase; ALT: alanine aminotransferase.