Skip to main content

Advertisement

Table 4 Auxological and biochemical parameters of patients with available target height, bone age, and biochemical data.

From: The Auxological and Biochemical Continuum of Short Children Born Small for Gestational Age (SGA) or with Normal Birth Size (Idiopathic Short Stature)

  Dimension All () ISS () SGA ()
Age at T1 Years 6.07 2.45 () 6.21 2.37 () 5.42 2.78 ()
Age at T2 (years) years 7.88 2.73 () 8.06 2.65 () 7.29 2.92 ()
Height at T1 SDS 2.83 0.69 2.72 0.54 3.32 0.94
Height at T2 SDS 2.66 0.61 2.53 0.42 3.26 0.91
Delta height gain SDS 0.08 0.2 0.1 0.19 0.02 0.24
Target height SDS 0.65 0.57 0.66 0.53 0.63 0.72
Ht at T2 minus THT SDS 2.01 0.73 1.87 0.56 2.63 1.06
Below target range ( %) 85 (74.6%) 68 (73%) 17 (81.0%)
BA-CA years 1.54 1.06 1.61 1.06 1.26 1.05
PAH SDS 1.83 1.08 () 1.71 1.05 () 2.4 1.09 ()
Ht-PAH SDS 0.71 1.01 () 0.76 ± 1.02 () 0.48 0.97 ()
Ht SDSPAH SDS ( %) 43 (75%) 37 (79%) 6 (60%)
PAH-THT SDS 1.14 1.12 () 1.01 1.18 () 1.78 0.96 ()
PAH SDStarget range (,%) 13 (22.8%) 9 (19.1%) 4 (40%)
IGF-I SDS 1.21 0.82 1.29 0.82 0.85 0.73
IGF-I 2 (,%) 19 (16.7%) 18 (19.4%) 1 (4.8%)
IGFBP-3 SDS 0.19 0.94 () 0.12 0.95 () 0.52 0.81 ()
IGFBP-3 SDS 2 ( %) 8 (7.3%) 6 (6.7%) 2 (10.5%)
  1. Mean (SD) are shown, except when indicated otherwise.
  2. T1: First prepubertal measurement
  3. T2: Timepoint of inclusion into the study
  4. Height SDS was calculated based on Prader et al. [10]
  5. Target height (TH) was calculated according to Hermanussen and Cole [11]
  6. Bone age (BA) minus chronological age (CA)
  7. Predicted adult height (PAH).