Table 4 Auxological and biochemical parameters of patients with available target height, bone age, and biochemical data.
Dimension | All ( | ISS ( | SGA ( | |
|---|---|---|---|---|
Age at T1 | Years | 6.07 | 6.21 | 5.42 |
Age at T2 (years) | years | 7.88 | 8.06 | 7.29 |
Height at T1 | SDS |
|
|
|
Height at T2 | SDS |
|
|
|
Delta height gain | SDS | 0.08 | 0.1 | 0.02 |
Target height | SDS |
|
|
|
Ht at T2 minus THT | SDS |
|
|
|
Below target range | ( | 85 (74.6%) | 68 (73%) | 17 (81.0%) |
BA-CA | years |
|
|
|
PAH | SDS |
|
|
|
Ht-PAH | SDS |
|
|
|
Ht SDS | ( | 43 (75%) | 37 (79%) | 6 (60%) |
PAH-THT | SDS |
|
|
|
PAH SDS | ( | 13 (22.8%) | 9 (19.1%) | 4 (40%) |
IGF-I | SDS |
|
|
|
IGF-I | ( | 19 (16.7%) | 18 (19.4%) | 1 (4.8%) |
IGFBP-3 | SDS | 0.19 | 0.12 | 0.52 |
IGFBP-3 SDS | ( | 8 (7.3%) | 6 (6.7%) | 2 (10.5%) |
)
)
)
2.45 (
)
2.37 (
)
2.78 (
)
2.73 (
)
2.65 (
)
2.92 (
)
2.83 
0.69
2.72 
0.54
3.32 
0.94
2.66 
0.61
2.53 
0.42
3.26 
0.91
0.2
0.19
0.24
0.65 
0.57
0.66 
0.53
0.63 
0.72
2.01 
0.73
1.87 
0.56
2.63 
1.06
%)
1.54 
1.06
1.61 
1.06
1.26 
1.05
1.83 
1.08 (
)
1.71 
1.05 (
)
2.4 
1.09 (
)
0.71 
1.01 (
)
0.76 ± 1.02 (
)
0.48 
0.97 (
)
PAH SDS
%)
1.14 
1.12 (
)
1.01 
1.18 (
)
1.78 
0.96 (
)
target range
,%)
1.21 
0.82
1.29 
0.82
0.85 
0.73
2
,%)
0.94 (
)
0.95 (
)
0.81 (
)
2
%)- Mean (SD) are shown, except when indicated otherwise.
- T1: First prepubertal measurement
- T2: Timepoint of inclusion into the study
Height SDS was calculated based on Prader et al. [10]
Target height (TH) was calculated according to Hermanussen and Cole [11]
Bone age (BA) minus chronological age (CA)
Predicted adult height (PAH).
Height SDS was calculated based on Prader et al. [
Target height (TH) was calculated according to Hermanussen and Cole [
Bone age (BA) minus chronological age (CA)
Predicted adult height (PAH).