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Table 5 Hormonal responses to GnRHag postdexamethasone. Post-GnRHag gonadotropin levels are shown at 4 hr and steroid levels at 22 hr. Mean  SEM (observed range).

From: LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity

 

Premature Adrenarche

SPPOPA

OW-PUB

PRE Reference Range [20]

 

Basal

Post-GnRHag

Basal

Post-GnRHag

Basal

Post-GnRHag

Basal

Post-GnRHag

LH

0.15  0.8

3.1  0.8

0.15  0.0

9.8  2.7

2.0  1.0

38  8.5

<0.15

1.0–7.0

(U/L)

(0.15)

(0.8–5.9)

(0.15)

(4.3–19)

(0.2–8.2)

(4.8–76)

  

FSH

1.4  0.2

21.4  3.9

1.1  0.2

26.4  7.3

3.1  0.7

24.9  2.7

0.4–1.7

7.9–32

(U/L)

(0.9–2.2)

(9.1–42)

(0.6–1.8)

(23–52)

(0.5–6.1)

(16.5–32)

  

LH/FSH

0.12  0.01

0.16  0.04

0.16  0.03

0.53  0.23

0.46  0.18

1.7  0.50

0.09–0.43

0.04–0.28

(Ratio)

(0.07–0.17)

(0.05–0.31)

(0.08–0.25)

(0.10–1.4)

(0.09–1.6)

(0.15–4.5)

  

E2

6.0  1.8

25.8  3.2

6.5  0.5

52.8  13.1

19.0  4.5

134  34.1

≤5.0–7.0

7.0–49

(pg/mL)

(≤5.0–10)

(16–39)

(≤5.0–8.0)

(19–95)

(≤5.0–39)

(23–298)

  

PROG

≤25  0.0

≤25  0.0

≤25  0.0

≤25  0.0

≤25  0.0

29.8  2.6

≤25

≤25

(ng/dl)

(25)

(25)

(25)

(25)

(25)

(25–44)

  

17OHP

≤25  0.0

≤25  0.0

≤25  0.0

25.8  0.4

≤25  0.0

73.0  18.2

≤25

≤25

(ng/dl)

(25)

(25)

(25)

(25–27)

(25)

(25–172)

  

DHEA

121  20.3

98.2  9.5

105  21

80.8  9.9

92.5  17.6

89.6  10.6

28–59

27–69

(ng/dl)

(67–212)

(77–129)

(50–162)

(42–96)

(41–158)

(44–125)

  

A'dione

30.1  3.8

28.0  1.6

28.4  3.4

37.9  8.9

43.9  7.9

76.6  17.4

≤25

25–40

(ng/dl)

(≤25–52)

(25–35)

(25–42)

(25–72)

(25–88)

(25–169)

  

Total T

≤10  0.0

≤10  0.0

12.2  2.3

11.5  0.6

15.2  2.4

18.3  3.5

≤10

≤10

(ng/dl)

(≤10)

(≤10)

(10–19)

(10–13)

(10–30)

(10–40)

  

Cortisol

2.0  0.3

1.6  0.2

2.0  0.3

1.5  0.3

2.0  0.6

1.5  0.3

1.0–3.0

1.0–5.0

(g/dl)

(1.0–3.0)

(1.0–2.0)

(1.0–3.0)

(0.9–2.0)

(0.9–2.0)

(0.9–3.0)

  
  1. versus OW-PUB .05.
  2. versus OW-PUB .01.
  3. versus SPPOPA .05.
  4. Conversions to SI units: DHEA  0.0347  nmol/L; for all other conversions, refer to Table 2.