LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity

Table 5 Hormonal responses to GnRHag postdexamethasone. Post-GnRHag gonadotropin levels are shown at 4 hr and steroid levels at 22 hr. Mean SEM (observed range).

	Premature Adrenarche		SPPOPA		OW-PUB		PRE Reference Range [20]
	Basal	Post-GnRHag	Basal	Post-GnRHag	Basal	Post-GnRHag	Basal	Post-GnRHag
LH	0.15 0.8	3.1 0.8	0.15 0.0	9.8 2.7	2.0 1.0	38 8.5	<0.15	1.0–7.0
(U/L)	(0.15)	(0.8–5.9)	(0.15)	(4.3–19)	(0.2–8.2)	(4.8–76)
FSH	1.4 0.2	21.4 3.9	1.1 0.2	26.4 7.3	3.1 0.7	24.9 2.7	0.4–1.7	7.9–32
(U/L)	(0.9–2.2)	(9.1–42)	(0.6–1.8)	(23–52)	(0.5–6.1)	(16.5–32)
LH/FSH	0.12 0.01	0.16 0.04	0.16 0.03	0.53 0.23	0.46 0.18	1.7 0.50	0.09–0.43	0.04–0.28
(Ratio)	(0.07–0.17)	(0.05–0.31)	(0.08–0.25)	(0.10–1.4)	(0.09–1.6)	(0.15–4.5)
E2	6.0 1.8	25.8 3.2	6.5 0.5	52.8 13.1	19.0 4.5	134 34.1	≤5.0–7.0	7.0–49
(pg/mL)	(≤5.0–10)	(16–39)	(≤5.0–8.0)	(19–95)	(≤5.0–39)	(23–298)
PROG	≤25 0.0	≤25 0.0	≤25 0.0	≤25 0.0	≤25 0.0	29.8 2.6	≤25	≤25
(ng/dl)	(25)	(25)	(25)	(25)	(25)	(25–44)
17OHP	≤25 0.0	≤25 0.0	≤25 0.0	25.8 0.4	≤25 0.0	73.0 18.2	≤25	≤25
(ng/dl)	(25)	(25)	(25)	(25–27)	(25)	(25–172)
DHEA	121 20.3	98.2 9.5	105 21	80.8 9.9	92.5 17.6	89.6 10.6	28–59	27–69
(ng/dl)	(67–212)	(77–129)	(50–162)	(42–96)	(41–158)	(44–125)
A'dione	30.1 3.8	28.0 1.6	28.4 3.4	37.9 8.9	43.9 7.9	76.6 17.4	≤25	25–40
(ng/dl)	(≤25–52)	(25–35)	(25–42)	(25–72)	(25–88)	(25–169)
Total T	≤10 0.0	≤10 0.0	12.2 2.3	11.5 0.6	15.2 2.4	18.3 3.5	≤10	≤10
(ng/dl)	(≤10)	(≤10)	(10–19)	(10–13)	(10–30)	(10–40)
Cortisol	2.0 0.3	1.6 0.2	2.0 0.3	1.5 0.3	2.0 0.6	1.5 0.3	1.0–3.0	1.0–5.0
(g/dl)	(1.0–3.0)	(1.0–2.0)	(1.0–3.0)	(0.9–2.0)	(0.9–2.0)	(0.9–3.0)

versus OW-PUB .05.
versus OW-PUB .01.
versus SPPOPA .05.
Conversions to SI units: DHEA 0.0347 nmol/L; for all other conversions, refer to Table 2.