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Table 1 Outline of study protocol.

From: LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity

Day

Clocktime

Procedure

Day 1

1900

Overnight hormonal sleep test

Day 2

0800

Baseline sampling begins

  

Oral glucose tolerance test

  

Pelvic ultrasound examination

 

1200

Dexamethasone 0.25 mg/m2 PO

 

1600

Basal sample for steroids

 

1601

ACTH1-24 (1.0 mcg/m2 IV) test begins

 

1700

Basal GnRHag test LH&FSH sampling begins

 

1800

GnRHag test (leuprolide 10 mcg/m2 SC) test begins

Day 3

1200

Post-GnRHag 18 hr sampling

 

1201

Dexamethasone 0.25 mg/m2 PO

 

1400

Post-GnRHag sampling resumes (20 hr)

 

1800

GnRHag test sampling ends (24 hr)