Responses of patients with congenital adrenocortical hyperplasia syndrome to cortisone in three daily doses as contrasted with those to single dose of dexamethasone at midnight. Black dots: values for daily excretion of urinary 17-ketosteroid; open circles: 24 hr excretion of pregnanetriol. Amount of medication in each period is shown by height of bars below abscissal scale. Patients (a) and (b) had "incomplete" form of 21-hydroxylase deficiency; (c) and (d) had "complete" salt-wasting variant. From .