Table 3 Baseline serum biomarkers of children with rickets compared to normal healthy children.
From: Nutritional Rickets among Children in a Sun Rich Country
Biochemistry parameters (units) | Rickets | Healthy control | P value |
|---|---|---|---|
|
| ||
| Â | n(%) | n(%) | Â |
Vitamin D deficiency | 97 (75.2) | 256 (62.5) | .009 |
Vitamin D deficiency Level (ng/ml) | Â | Â | Â |
Optimum Level (20–80) | 32 (24.8) | 154 (37.5) | .008 |
Mild to Moderate (10–20) | 56 (43.4) | 177 (43.0) |  |
Severe Deficiency ( | 41 (31.8) | 80 (19.5) | Â |
| Â |
(Mean
|
(Mean
| Â |
Vitamin D serum concentration (ng/ml) | 14.5 | 23.3 | .0001 |
Magnesium (mg/dl) | 1.6 | 2.1 | .001 |
Phosphorus (mg/dl) | 2.0 | 4.3 | .001 |
Blood urea nitrogen | 6.5 | 4.2 | .002 |
PTH (pg/ml) | 218.7 | 29.8 | .001 |
Creatinine ( | 49.8 | 43.4 | .012 |
Outcome of 6 weeks treatment Calcium, (mg/dl) | n(%) | n(%) | Â |
| 44 (34.1) | 29 (7.1) | .0001 |
2.13–2.63 | 72 (55.8) | 316 (76.8) |  |
| 13 (10.1) | 66 (16.1) | Â |
Serum alkaline phosphatase IU/L | Â | Â | Â |
| 25 (19.4) | 304 (74.0) | .0001 |
500–1000 | 41 (31.8) | 78 (18.9) |  |
  | 63 (48.8) | 29 (7.1) |  |
25(OH)VitD 3 nmol/L | Â | Â | Â |
| 97 (75.2) | 257 (62.5) | .0001 |
| 32 (24.8) | 154 (37.5) | Â |
10)
SD)
SD)
8.6
13.4
0.5
0.6
1.2
1.7
3.4
2.9
96.5
9.8
mol/L)
12.9
13.6
2.13
2.63
500
1000
20
20