Table 1 Adverse events associated with methimazole.
From: Adverse Events Associated with Methimazole Therapy of Graves' Disease in Children
Age at diagnosis | Gender | MMI dose at time | Duration of therapy | Reaction |
|---|---|---|---|---|
of AE (mg/day) | at time of AE | |||
3 5/12 | M | 10 | 12 weeks | Mild liver injury |
4 | M | 10 | 32 weeks | Myalgias/joint pain/facial urticaria |
4 4/12 | F | 10 | 2 weeks | Pruritis and hives |
4 3/4 | F | 30 | 2 weeks | Stevens-Johnson syndrome |
5 1/12 | F | 7.5 | 3 weeks | Diffuse urticaria |
7 10/12 | F | 15 | 4 weeks | Arthralgia |
8 2/12 | F | 10 | 2 weeks | Rash and joint pain |
8 4/12 | F | 10 | 3 weeks | Urticaria |
8 5/12 | M | 20 | 9 weeks | Arthralgia |
8 10/12* | M | 10 | 18 months | Neutropenia (ANCA+) |
8 10/12* | M | 10 | 18 months | Neutropenia (ANCA−) |
10 7/12 | M | 40 | 4 weeks | Myalgias |
11 1/2 | F | 20 | 4 weeks | Lymphopenia and eosinophilia |
12 5/12 | F | 20 | 12 weeks | Myalgias |
12 6/12 | F | 30 | 12 weeks | Stevens-Johnson syndrome (hospitalization) |
14 2/12 | F | 30 | 4 weeks | Stevens-Johnson, syndrome |
15 4/12 | F | 30 | 2 weeks | Rash |
16 11/12 | F | 20 | 4 weeks | Rash on arms and face |
17 6/12 | F | 30 | 3 weeks | Pruritic rash |