Table 4 PWS patients experiencing an oxygen desaturation.
Patient (sex) | Age mos | Visit # | Receiving Growth Hormone | Clonidine dose, mg ( | Sleep onset (min) | Lowest SpO2(%) | BMI | BMI Z-score | Comments |
|---|---|---|---|---|---|---|---|---|---|
1 (F) • 15q11-13 deletion• No history of sleep apnea | 9 | 1 | No | 0.06 (7.1) | 30 | 89% | 17.3 | 0.37 | Current upper respiratory infection |
| Â | 20 | 2 | Yes | 0.075 (6.1) | 20 | 93% | 16.3 | 0.51 | Current upper respiratory infectionSonorous respirations |
2 (F)• 15q11-13 deletion • No history of sleep apnea• History of snoring | 17 | 2 | Yes | 0.05 (4.9) | 30 | 91% | 16.7 | 0.62 | — |
|  | 29 | 3 | Yes | 0.05 (4.0) | 30 | 90% | NR | NR | — |
3 (F) • 15q11-13 deletion• History of sleep apnea• History of snoring | 27 | 2 | No | 0.025 (2.0) (dose reduced) | 45 | 92% | 15.8 | 0.15 | Current upper respiratory infectionNo snoring |
| Â | 39 | 3 | Yes | 0.05 (2.6) (dose reduced) | 37 | 93% | 20.7 | 3.18 | Current upper respiratory infectionMild airway obstruction |
4 (F) • 15q11-13 deletion• History of respiratory pauses during sleep | 28 | 2 | No | 0.07 (5.9) | 33 | 92% | 16.3 | 0.53 | Irregular breathing with pauses |
|  | 40 | 3 | Yes | 0.075 (6.4) | 53 | 94% | 14.2 | −0.90 | — |
5 (F) • 15q11-13 deletion • Occasional snoring | 48 | 4 | Yes | 0.125 (5.9) | 31 | 94% | 16.1 | 0.58 | Sonorous respirations |
g/kg)
- Characteristics of the 5 patients experiencing an oxygen desaturation on 9 separate occasions.
BMI Z-scores were computed with the LMS method using WHO reference values for gender and age.- NR—Not recorded.
BMI Z-scores were computed with the LMS method using WHO reference values for gender and age.