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Table 4 PWS patients experiencing an oxygen desaturation.

From: Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Patient (sex) Age mos Visit # Receiving Growth Hormone Clonidine dose, mg (g/kg) Sleep onset (min) Lowest SpO2(%) BMI BMI Z-score Comments
1 (F) • 15q11-13 deletion• No history of sleep apnea 9 1 No 0.06 (7.1) 30 89% 17.3 0.37 Current upper respiratory infection
  20 2 Yes 0.075 (6.1) 20 93% 16.3 0.51 Current upper respiratory infectionSonorous respirations
2 (F)• 15q11-13 deletion • No history of sleep apnea• History of snoring 17 2 Yes 0.05 (4.9) 30 91% 16.7 0.62
  29 3 Yes 0.05 (4.0) 30 90% NR NR
3 (F) • 15q11-13 deletion• History of sleep apnea• History of snoring 27 2 No 0.025 (2.0) (dose reduced) 45 92% 15.8 0.15 Current upper respiratory infectionNo snoring
  39 3 Yes 0.05 (2.6) (dose reduced) 37 93% 20.7 3.18 Current upper respiratory infectionMild airway obstruction
4 (F) • 15q11-13 deletion• History of respiratory pauses during sleep 28 2 No 0.07 (5.9) 33 92% 16.3 0.53 Irregular breathing with pauses
  40 3 Yes 0.075 (6.4) 53 94% 14.2 −0.90
5 (F) • 15q11-13 deletion • Occasional snoring 48 4 Yes 0.125 (5.9) 31 94% 16.1 0.58 Sonorous respirations
  1. Characteristics of the 5 patients experiencing an oxygen desaturation on 9 separate occasions.
  2. BMI Z-scores were computed with the LMS method using WHO reference values for gender and age.
  3. NR—Not recorded.