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Table 3 Percentage changes of individual vital sign parameters following clonidine administration for each study period and overall.

From: Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Period Oxygen saturation (%) Heart rate Respiratory rate
  Mean SD P-value Mean SD P –value Mean SD P -value
1 −2.3 1.7 <.001 −20.8 7.8 <.001 −32.3 17.1 <.001
2 −2.3 2.1 .001 −16.7 9.6 .000 −26.6 16.4 <.001
3 −2.3 2.7 .005 −8.9 23.8 .170 −25.6 20.8 .001
4 −1.7 1.9 .010 −16.6 7.4 .000 −18.4 17.3 .004
Overall −2.1 2.1 <.001 −15.9 14.3 <.001 −26.3 18.1 <.001
Period Systolic blood pressure Diastolic blood pressure    
  Mean SD P -value Mean SD P -value    
1 −19.1 10.8 .000 −6.3 40.6 .532    
2 −18.8 11.1 .000 −13.7 48.8 .296    
3 −14.6 11 .000 −22 13.4 .000    
4 −20.2 16 .001 −20.1 22.8 .011    
Overall −18.2 12.0 <.001 −14.7 35.6 .005    
  1. -value was calculated using a paired -test for study periods 1–4; a repeated measurement model with autoregressive correlation structure was used to compute -value for overall comparison.