Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Table 1 Patient population.

	Study period
	Overall	#1	#2	#3	#4
Number of patients studied	17	17	16	15	12
Mean age (months)	30.4 ± 15.0	14.0 ± 6.8	26.1 ± 7.2	37.6 ± 6.9	50.2 ± 7.5
Male/Female	7/10	7/10	7/9	6/9	5/7
Mean clonidine dose (mg)	0.074 ± 0.027	0.058 ± 0.011	0.062 ± 0.021	0.072 ± 0.018	0.113 ± 0.02
Mean clonidine dose per kg (g/kg)	5.3 ± 1.72	6.56 ± 1.08	5.09 ± 1.75	4.37 ± 1.18	4.97 ± 1.0

A total of 60 study periods were conducted over a 3-year period. Each study period was approximately 12 months apart. Seventeen patients were initially enrolled in the study. Twelve patients completed all four study periods. Overall refers to the mean age and clonidine dose for all 60 study periods.

ISSN: 1687-9856