From: Fibroblast Growth Factor 23 (FGF23) and Disorders of Phosphate Metabolism
 | Genetic diseases |
---|---|
FGF23-related rickets | Autosomal dominant hypophosphatemic rickets/osteomalacia |
 | (mutations in FGF23 gene) |
 | Autosomal recessive hypophosphatemic rickets/osteomalacia |
 | (mutations in DMP1 gene) |
 | X-linked hypophosphatemic rickets/osteomalacia |
 | (mutations in PHEX gene) |
 | McCune-Albright syndrome/Fibrous dysplasia |
 | (somatic mutations in GNAS1 gene) |
Deficient action of 1,25(OH)2D | Vitamin D-dependent rickets type 1 |
 | (mutations in CYP27B1 gene) |
 | Vitamin D-dependent rickets type 2 (mutations in VDR gene) |
Dysfunction of renal tubules | Fanconi syndrome |
 | Dent disease (mutations in CLCN5 gene) |
 | Some renal tubular acidosis |
Others | Hereditary hypophosphatemic rickets/osteomalacia with hypercalcemia |
 | (mutations in SLC34A3 gene) |
 | Hypophosphatasia (mutations in TNALP gene) |
 | Acquired diseases |
FGF23-related rickets/osteomalacia | Tumor-induced hypophosphatemic rickets/osteomalacia |
Deficiency of vitamin D or phosphate | Premature birth |
 | Undernutrition |
 | Vitamin D deficiency, shortage of daylight |
Drug-induced rickets/osteomalacia | Antiepileptic drugs, Saccharated ferric oxide (Iron polymaltose), Aluminum, and so forth |
Others | Chronic renal disease, and so forth |